STRUCTURAL SIGNIFICANCE OF THE GTP-BINDING DOMAIN OF RAS P21 STUDIED BY SITE-DIRECTED MUTAGENESIS

被引：52

作者：

CLANTON, DJ ^{[1
]}

LU, YY ^{[1
]}

BLAIR, DG ^{[1
]}

SHIH, TY ^{[1
]}

机构：

[1] NCI,MOLEC ONCOL LAB,FREDERICK,MD 21701

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1987年 / 7卷 / 09期

关键词：

D O I：

10.1128/MCB.7.9.3092

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：3092 / 3097

页数：6

共 34 条

[1] AMINO-ACID SUBSTITUTIONS AT CODON-13 OF THE N-RAS ONCOGENE IN HUMAN ACUTE MYELOID-LEUKEMIA [J].

BOS, JL ;

TOKSOZ, D ;

MARSHALL, CJ ;

VERLAANDEVRIES, M ;

VEENEMAN, GH ;

VANDEREB, AJ ;

VANBOOM, JH ;

JANSSEN, JWG ;

STEENVOORDEN, ACM .

NATURE, 1985, 315 (6022) :726-730

[2] GTP-BINDING PROTEINS - ONE MOLECULAR MACHINE CAN TRANSDUCE DIVERSE SIGNALS [J].

BOURNE, HR .

NATURE, 1986, 321 (6073) :814-816

[3] FUNCTIONAL-ORGANIZATION OF THE HARVEY MURINE SARCOMA-VIRUS GENOME [J].

CHANG, EH ;

MARYAK, JM ;

WEI, CM ;

SHIH, TY ;

SHOBER, R ;

CHEUNG, HL ;

ELLIS, RW ;

HAGER, GL ;

SCOLNICK, EM ;

LOWY, DR .

JOURNAL OF VIROLOGY, 1980, 35 (01) :76-92

[4] ACTIVATION OF HA-RAS P21 BY SUBSTITUTION, DELETION, AND INSERTION MUTATIONS [J].

CHIPPERFIELD, RG ;

JONES, SS ;

LO, KM ;

WEINBERG, RA .

MOLECULAR AND CELLULAR BIOLOGY, 1985, 5 (08) :1809-1813

[5] MUTATIONS OF THE RAS GENE-PRODUCT P21 THAT ABOLISH GUANINE-NUCLEOTIDE BINDING [J].

CLANTON, DJ ;

HATTORI, S ;

SHIH, TY .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (14) :5076-5080

[6] BIOLOGICAL AND BIOCHEMICAL-PROPERTIES OF HUMAN RASH GENES MUTATED AT CODON-61 [J].

DER, CJ ;

FINKEL, T ;

COOPER, GM .

CELL, 1986, 44 (01) :167-176

[7] ISOLATION OF RAS GTP-BINDING MUTANTS USING AN INSITU COLONY-BINDING ASSAY [J].

FEIG, LA ;

PAN, BT ;

ROBERTS, TM ;

COOPER, GM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (13) :4607-4611

[8] ACTIVATION OF RAS GENES IN HUMAN-TUMORS DOES NOT AFFECT LOCALIZATION, MODIFICATION, OR NUCLEOTIDE BINDING-PROPERTIES OF P21 [J].

FINKEL, T ;

DER, CJ ;

COOPER, GM .

CELL, 1984, 37 (01) :151-158

[9] ATP-BINDING SITE OF ADENYLATE KINASE - MECHANISTIC IMPLICATIONS OF ITS HOMOLOGY WITH RAS-ENCODED P21, F1-ATPASE, AND OTHER NUCLEOTIDE-BINDING PROTEINS [J].

FRY, DC ;

KUBY, SA ;

MILDVAN, AS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (04) :907-911

[10] AUTOPHOSPHORYLATION OF V-HA-RAS-P21 IS MODULATED BY AMINO-ACID RESIDUE-12 [J].

GIBBS, JB ;

ELLIS, RW ;

SCOLNICK, EM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (09) :2674-2678

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