Analgesic and Anti-Inflammatory Activity of Sophora Mollis (Leguminosae) Leaves and Stem Extracts in Mice

被引:0
|
作者
Bazmi, Rizwan Rashid [1 ]
Javed, Ibrahim [1 ]
Salman, Usman Ghani [1 ]
Razi, Muhammad Tahir [1 ]
Rasool, Nasir [2 ]
机构
[1] Bahauddin Zakariya Univ, Fac Pharm, Dept Pharmaceut Chem, Bosan Rd, Multan 60000, Punjab, Pakistan
[2] Govt Coll Univ, Dept Chem, Faisalabad 38000, Punjab, Pakistan
来源
INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND PHYTOPHARMACOLOGICAL RESEARCH | 2014年 / 3卷 / 05期
关键词
Sophora mollis; Analgesic; Antiinflammatory; Saponins; Alkaloids; Tannins;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Sophora mollis (Leguminosae) is used as traditional medicine against skin diseases, rheumatism and as anthelmintic in Nepal and other regions of Asia. Its analgesic and anti-inflammatory potential was not yet examined. The aim of this study was therefore to evaluate antinociceptive and anti-inflammatory activities of this plant in mice models. Methanolic and ethyl acetate extracts of stem and leaves were evaluated separately at the doses of 200 and 500mg/kg in comparison with standard reference of aspirin (300mg/kg). Analgesic potential was examined via hot-plate test and acetic acid induced writhing while anti-inflammatory effects were evaluated in formalin induced inflammation model. Extracts showed significant antinociceptive potential particularly methanolic extract of stem showed dose dependant analgesia comparable to high dose of aspirin. Anti-inflammatory effects were significant in both phases of inflammation and were in comparison with aspirin and codeine sulphate. Preliminary phytochemical screening revealed strong presence of saponins, tannins and alkaloids.
引用
收藏
页码:374 / 377
页数:4
相关论文
共 50 条
  • [1] Analgesic and anti-inflammatory effects of Pistacia integerrima extracts in mice
    Ahmad, Naseem Saud
    Waheed, Akbar
    Farman, Muhammad
    Qayyum, Aisha
    JOURNAL OF ETHNOPHARMACOLOGY, 2010, 129 (02) : 250 - 253
  • [2] Papaver rhoeas L. stem and flower extracts: Anti-struvite, anti-inflammatory, analgesic, and antidepressant activities
    Hmamou, Anouar
    El-Assri, El-Mehdi
    El Khomsi, Mostafa
    Kara, Mohammed
    Alshawwa, Samar Zuhair
    Al Kamaly, Omkulthom
    Oumari, Fatima Ezzahra El
    Eloutassi, Noureddine
    Lahkimi, Amal
    SAUDI PHARMACEUTICAL JOURNAL, 2023, 31 (08)
  • [3] Anti-inflammatory and analgesic activity based on polymorphism of cedrol in mice
    Wang, Jie-wen Y.
    Chen, Shan-shan
    Zhang, Yu-meng
    Guan, Jian
    Su, Guang-yue
    Ding, Meng
    Li, Wei
    Zhao, Yu-Qing
    ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2019, 68 : 13 - 18
  • [4] Analgesic and anti-inflammatory activity of Cotinus coggygria Scop. extracts in vivo
    Lu, Kai
    Yang, Chong-Yu
    Yan, Zhao-Hong
    ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE, 2024, 14 (06) : 225 - 235
  • [5] Analgesic and anti-inflammatory effects of Cassia siamea Lam. stem bark extracts
    Ntandou, G. F. Nsonde
    Banzouzi, J. T.
    Mbatchi, B.
    Elion-Itou, R. D. G.
    Etou-Ossibi, A. W.
    Ramos, S.
    Benoit-Vical, F.
    Abena, A. A.
    Ouamba, J. M.
    JOURNAL OF ETHNOPHARMACOLOGY, 2010, 127 (01) : 108 - 111
  • [6] Analgesic and Anti-inflammatory Activity of Teucrium chamaedrys Leaves Aqueous Extract in Male Rats
    Pourmotabbed, Ali
    Farshchi, Amir
    Ghiasi, Golbarg
    Khatabi, Peyman Malek
    IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2010, 13 (03) : 119 - 125
  • [7] Anti-inflammatory and analgesic activity of Uraria lagopoides
    Hamid, F
    Abdullah, ST
    Ali, A
    Alam, MS
    Ansari, SH
    PHARMACEUTICAL BIOLOGY, 2004, 42 (02) : 114 - 116
  • [8] Anti-inflammatory, analgesic and antipyretic activity of aqueous extract of fresh leaves of Coccinia indica
    Niazi J.
    Singh P.
    Bansal Y.
    Goel R.K.
    Inflammopharmacology, 2009, 17 (4) : 239 - 244
  • [9] Anti-inflammatory and analgesic properties of the stem bark extracts of Erythrophleum suaveolens (Caesalpiniaceae), Guillemin & Perrottet
    Dongmo, AB
    Kamanyi, A
    Anchang, MS
    Nkeh, BCA
    Njamen, D
    Nguelefack, TB
    Nole, T
    Wagner, H
    JOURNAL OF ETHNOPHARMACOLOGY, 2001, 77 (2-3) : 137 - 141
  • [10] Evaluation of phytochemical constituents, analgesic, anti-inflammatory, antimicrobial and antioxidant activities of extracts of Breynia nivosa leaves
    Onyegbule, F. A.
    Ilouno, I. O.
    Ikeh, C.
    Umeokoli, B. O.
    Eze, P. M.
    PLANTA MEDICA, 2014, 80 (16) : 1544 - 1545