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Analgesic and Anti-Inflammatory Activity of Sophora Mollis (Leguminosae) Leaves and Stem Extracts in Mice
被引:0
|作者:
Bazmi, Rizwan Rashid
[1
]
Javed, Ibrahim
[1
]
Salman, Usman Ghani
[1
]
Razi, Muhammad Tahir
[1
]
Rasool, Nasir
[2
]
机构:
[1] Bahauddin Zakariya Univ, Fac Pharm, Dept Pharmaceut Chem, Bosan Rd, Multan 60000, Punjab, Pakistan
[2] Govt Coll Univ, Dept Chem, Faisalabad 38000, Punjab, Pakistan
来源:
INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND PHYTOPHARMACOLOGICAL RESEARCH
|
2014年
/
3卷
/
05期
关键词:
Sophora mollis;
Analgesic;
Antiinflammatory;
Saponins;
Alkaloids;
Tannins;
D O I:
暂无
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
Sophora mollis (Leguminosae) is used as traditional medicine against skin diseases, rheumatism and as anthelmintic in Nepal and other regions of Asia. Its analgesic and anti-inflammatory potential was not yet examined. The aim of this study was therefore to evaluate antinociceptive and anti-inflammatory activities of this plant in mice models. Methanolic and ethyl acetate extracts of stem and leaves were evaluated separately at the doses of 200 and 500mg/kg in comparison with standard reference of aspirin (300mg/kg). Analgesic potential was examined via hot-plate test and acetic acid induced writhing while anti-inflammatory effects were evaluated in formalin induced inflammation model. Extracts showed significant antinociceptive potential particularly methanolic extract of stem showed dose dependant analgesia comparable to high dose of aspirin. Anti-inflammatory effects were significant in both phases of inflammation and were in comparison with aspirin and codeine sulphate. Preliminary phytochemical screening revealed strong presence of saponins, tannins and alkaloids.
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页码:374 / 377
页数:4
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