DIFFERENTIAL SPLICING OF ALZHEIMERS-DISEASE AMYLOID A4 PRECURSOR RNA IN RAT-TISSUES - PREA4695 MESSENGER-RNA IS PREDOMINANTLY PRODUCED IN RAT AND HUMAN BRAIN

被引：153

作者：

KANG, J

MULLERHILL, B

机构：

[1] Institut für Genetik der Universität zu Köln, D-5000 Köln 41

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 166卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)90992-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's disease is characterized by filamentous depositions of amyloid A4 protein in the brain. The first precursor of A4 protein that has been described consists of 695 amino acids (PreA4695). Until now, three types of amyloid precursor mRNAs (PreA4770, PreA4751 and PreA4695), produced by alternative splicing, have been detected. We analysed the differential expression of these mRNAs in various rat tissues by PCR and show that (1) there exists a fourth type of mRNA, PreA4714; (2) in all tissues except the brain the PreA4695 mRNA is less abundant than the other types of mRNAs; in the brain, however, the PreA4695 mRNA predominates by far. The same observations hold true for human tissues. The possible function of this differential splicing is discussed. © 1990.

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页码：1192 / 1200

页数：9

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