Hemorrhagic transformation after cerebral infarction: current concepts and challenges

被引:218
作者
Zhang, Jie [1 ]
Yang, Yi [1 ]
Sun, Huijie [2 ]
Xing, Yingqi [1 ]
机构
[1] Jilin Univ, Hosp Jilin Univ 1, Neurosci Ctr, Dept Neurol, Changchun 130021, Jilin, Peoples R China
[2] Jilin Univ, Hosp Jilin Univ 1, Cadre Ward, Changchun 130021, Jilin, Peoples R China
关键词
Acute ischemic stroke; hemorrhagic transformation (HT);
D O I
10.3978/j.issn.2305-5839.2014.08.08
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Hemorrhagic transformation (HT) is a frequent complication of acute ischemic stroke that is especially common after thrombolytic therapy. The risk of HT limits the applicability of tissue plasminogen activator (tPA). Here, we sought to review the rate, classification, predictors, possible mechanism, and clinical outcomes of HT, as well as existing therapeutic approaches, in order to call attention to the current challenges in the treatment of this complication.
引用
收藏
页数:7
相关论文
共 56 条
[21]   Hemorrhagic transformation in acute ischemic stroke - The MAST-E study [J].
Jaillard, A ;
Cornu, C ;
Durieux, A ;
Moulin, T ;
Boutitie, F ;
Lees, KR ;
Hommel, M .
STROKE, 1999, 30 (07) :1326-1332
[22]   Predictors and Early Outcome of Hemorrhagic Transformation after Acute Ischemic Stroke [J].
Kablau, Micha ;
Kreisel, Stefan H. ;
Sauer, Tamara ;
Binder, Johannes ;
Szabo, Kristina ;
Hennerici, Michael G. ;
Kern, Rolf .
CEREBROVASCULAR DISEASES, 2011, 32 (04) :334-341
[23]   Factors influencing hemorrhagic transformation in ischemic stroke:: a clinicopathological comparison [J].
Kerenyi, L. ;
Kardos, L. ;
Szasz, J. ;
Szatmari, S. ;
Bereczki, D. ;
Hegedus, K. ;
Csiba, L. .
EUROPEAN JOURNAL OF NEUROLOGY, 2006, 13 (11) :1251-1255
[24]   Blood-brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke [J].
Khatri, Rakesh ;
McKinney, Alexander M. ;
Swenson, Barbara ;
Janardhan, Vallabh .
NEUROLOGY, 2012, 79 (13) :S52-S57
[25]   Predictors of hemorrhagic transformation in patients receiving intra-arterial thrombolysis [J].
Kidwell, CS ;
Saver, JL ;
Carneado, J ;
Sayre, J ;
Starkman, S ;
Duckwiler, G ;
Gobin, YP ;
Jahan, R ;
Vespa, P ;
Villablanca, JP ;
Liebeskind, DS ;
Vinuela, F .
STROKE, 2002, 33 (03) :717-724
[26]   Low Level of Low-Density Lipoprotein Cholesterol Increases Hemorrhagic Transformation in Large Artery Atherothrombosis but Not in Cardioembolism [J].
Kim, Beom Joon ;
Lee, Seung-Hoon ;
Ryu, Wi-Sun ;
Kang, Bong Su ;
Kim, Chi Kyung ;
Yoon, Byung-Woo .
STROKE, 2009, 40 (05) :1627-1632
[27]   The Role of Complement in Stroke Therapy [J].
Komotar, Ricardo J. ;
Kim, Grace H. ;
Often, Marc L. ;
Hassid, Benjamin ;
Mocco, J. ;
Sughrue, Michael E. ;
Starke, Robert M. ;
Mack, William J. ;
Ducruet, Andrew F. ;
Merkow, Maxwell B. ;
Garrett, Matthew C. ;
Connolly, E. Sander .
CURRENT TOPICS IN COMPLEMENT II, 2008, 632 :23-33
[28]   Hemorrhagic transformation of ischemic stroke in diabetics on sulfonylureas [J].
Kunte, Hagen ;
Busch, Markus A. ;
Trostdorf, Katrin ;
Vollnberg, Bernd ;
Harms, Lutz ;
Mehta, Rupal I. ;
Castellani, Rudolf J. ;
Mandava, Pitchaiah ;
Kent, Thomas A. ;
Simard, J. Marc .
ANNALS OF NEUROLOGY, 2012, 72 (05) :799-806
[29]   Symptomatic Hemorrhagic Transformation and Its Predictors in Acute Ischemic Stroke with Atrial Fibrillation [J].
Lee, Ju-Hun ;
Park, Kwang-Yeol ;
Shin, Joon-Hyun ;
Cha, Jae-Kwan ;
Kim, Hahn-Young ;
Kwon, Jae-Hyun ;
Oh, Hyung Geun ;
Lee, Kyung Bok ;
Kim, Dong-Eog ;
Ha, Sang-Won ;
Cho, Kyung-Hee ;
Sohn, Sung-Il ;
Oh, Mi-Sun ;
Yu, Kyung-Ho ;
Lee, Byung-Chul ;
Kwon, Sun U. .
EUROPEAN NEUROLOGY, 2010, 64 (04) :193-200
[30]   Low Glomerular Filtration Rate Increases Hemorrhagic Transformation in Acute Ischemic Stroke [J].
Lee, Jung-Gon ;
Lee, Kyung Bok ;
Jang, Il-Mi ;
Roh, Hakjae ;
Ahn, Moo-Young ;
Woo, Hee-Yeon ;
Hwang, Hye-Won .
CEREBROVASCULAR DISEASES, 2013, 35 (01) :53-59