Hemorrhagic transformation after cerebral infarction: current concepts and challenges

被引:218
作者
Zhang, Jie [1 ]
Yang, Yi [1 ]
Sun, Huijie [2 ]
Xing, Yingqi [1 ]
机构
[1] Jilin Univ, Hosp Jilin Univ 1, Neurosci Ctr, Dept Neurol, Changchun 130021, Jilin, Peoples R China
[2] Jilin Univ, Hosp Jilin Univ 1, Cadre Ward, Changchun 130021, Jilin, Peoples R China
关键词
Acute ischemic stroke; hemorrhagic transformation (HT);
D O I
10.3978/j.issn.2305-5839.2014.08.08
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Hemorrhagic transformation (HT) is a frequent complication of acute ischemic stroke that is especially common after thrombolytic therapy. The risk of HT limits the applicability of tissue plasminogen activator (tPA). Here, we sought to review the rate, classification, predictors, possible mechanism, and clinical outcomes of HT, as well as existing therapeutic approaches, in order to call attention to the current challenges in the treatment of this complication.
引用
收藏
页数:7
相关论文
共 56 条
[1]   Emergent use of anticoagulation for treatment of patients with ischemic stroke [J].
Adams, HP .
STROKE, 2002, 33 (03) :856-861
[2]   Cholesterol level and symptomatic hemorrhagic transformation after ischemic stroke thrombolysis [J].
Bang, O. Y. ;
Saver, J. L. ;
Liebeskind, D. S. ;
Starkman, S. ;
Villablanca, P. ;
Salamon, N. ;
Buck, B. ;
Ali, L. ;
Restrepo, L. ;
Vinuela, F. ;
Duckwiler, G. ;
Jahan, R. ;
Razinia, T. ;
Ovbiagele, B. .
NEUROLOGY, 2007, 68 (10) :737-742
[3]   Collateral Flow Averts Hemorrhagic Transformation After Endovascular Therapy for Acute Ischemic Stroke [J].
Bang, Oh Young ;
Saver, Jeffrey L. ;
Kim, Suk Jae ;
Kim, Gyeong-Moon ;
Chung, Chin-Sang ;
Ovbiagele, Bruce ;
Lee, Kwang Ho ;
Liebeskind, David S. .
STROKE, 2011, 42 (08) :2235-U329
[4]   Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke [J].
Brott, T ;
Broderick, J ;
Kothari, R ;
ODonoghue, M ;
Barsan, W ;
Tomsick, T ;
Spilker, J ;
Miller, R ;
Sauerbeck, L ;
Farrell, J ;
Kelly, J ;
Perkins, T ;
Miller, R ;
McDonald, T ;
Rorick, M ;
Hickey, C ;
Armitage, J ;
Perry, C ;
Thalinger, K ;
Rhude, R ;
Schill, J ;
Becker, PS ;
Heath, RS ;
Adams, D ;
Reed, R ;
Klei, M ;
Hughes, A ;
Anthony, J ;
Baudendistel, D ;
Zadicoff, C ;
Rymer, M ;
Bettinger, I ;
Laubinger, P ;
Schmerler, M ;
Meiros, G ;
Lyden, P ;
Dunford, J ;
Zivin, J ;
Rapp, K ;
Babcock, T ;
Daum, P ;
Persona, D ;
Brody, M ;
Jackson, C ;
Lewis, S ;
Liss, J ;
Mahdavi, Z ;
Rothrock, J ;
Tom, T ;
Zweifler, R .
STROKE, 1997, 28 (11) :2109-2118
[5]   Combining Statins with Tissue Plasminogen Activator Treatment After Experimental and Human Stroke: A Safety Study on Hemorrhagic Transformation [J].
Campos, Mireia ;
Garcia-Bonilla, Lidia ;
Hernandez-Guillamon, Mar ;
Barcelo, Veronica ;
Morancho, Anna ;
Quintana, Manolo ;
Rubiera, Marta ;
Rosell, Anna ;
Montaner, Joan .
CNS NEUROSCIENCE & THERAPEUTICS, 2013, 19 (11) :863-870
[6]   Plasma cellular-fibronectin concentration predicts hemorrhagic transformation after thrombolytic therapy in acute ischemic stroke [J].
Castellanos, M ;
Leira, R ;
Serena, J ;
Blanco, M ;
Pedraza, S ;
Castillo, J ;
Dávalos, A .
STROKE, 2004, 35 (07) :1671-1676
[7]   Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke [J].
Castellanos, M ;
Leira, R ;
Serena, J ;
Pumar, JM ;
Lizasoain, I ;
Castillo, J ;
Dávalos, A .
STROKE, 2003, 34 (01) :40-45
[8]   Prediction of hemorrhagic transformation in acute ischaemic stroke by micro- and macroalbuminuria after intravenous thrombolysis [J].
Cho, B. -H. ;
Kim, J. -T. ;
Chang, J. ;
Choi, K. -H. ;
Park, M. -S. ;
Cho, K. -H. .
EUROPEAN JOURNAL OF NEUROLOGY, 2013, 20 (08) :1145-1152
[9]   The serum ferritin level is an important predictor of hemorrhagic transformation in acute ischaemic stroke [J].
Choi, K. -H. ;
Park, M. -S. ;
Kim, J. -T. ;
Nam, T. -S. ;
Choi, S. -M. ;
Kim, B. -C. ;
Kim, M. -K. ;
Cho, K. -H. .
EUROPEAN JOURNAL OF NEUROLOGY, 2012, 19 (04) :570-577
[10]   Early and Late Mortality of Spontaneous Hemorrhagic Transformation of Ischemic Stroke [J].
D'Amelio, Marco ;
Terruso, Valeria ;
Famoso, Giorgia ;
Di Benedetto, Norma ;
Realmuto, Sabrina ;
Valentino, Francesca ;
Ragonese, Paolo ;
Savettieri, Giovanni ;
Aridon, Paolo .
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2014, 23 (04) :649-654