PRIMARY SWINE INTESTINAL-CELLS AS A MODEL FOR STUDYING CAMPYLOBACTER-JEJUNI INVASIVENESS

被引：20

作者：

BABAKHANI, FK ^{[1
]}

JOENS, LA ^{[1
]}

机构：

[1] UNIV ARIZONA,DEPT VET SCI,TUCSON,AZ 85721

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 06期

关键词：

D O I：

10.1128/IAI.61.6.2723-2726.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Swine small-intestinal enterocytes were used to test the invasiveness of Campylobacter jejuni. The cells were removed from the small intestines of 6-h-old piglets by enzymatic digestion. Two clinical C. jejuni isolates invaded swine enterocytes at significantly higher frequencies than an Escherichia coli control strain. The recovered colonies of C. jejuni T13192 appeared to be highly mucoid and invaded tissue culture cells (INT 407) at higher frequency (0.14%) than the parental strain (0.003%). The data not only support the previous in vitro findings regarding the invasiveness of C. jejuni but also suggest that invasiveness of C. jejuni may be an in vivo virulence attribute.

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页码：2723 / 2726

页数：4

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