USE OF A 3-PHASE MODEL WITH HYDROXYPROPYL-BETA-CYCLODEXTRIN FOR THE DIRECT DETERMINATION OF LARGE OCTANOL WATER AND CYCLODEXTRIN WATER PARTITION-COEFFICIENTS

被引：16
作者：
MENGES, RA
ARMSTRONG, DW
机构：
[1] Department of Chemistry, University of Missouri-Rolla, Rolla
来源：
ANALYTICA CHIMICA ACTA | 1991年 / 255卷 / 01期
关键词：
LIQUID CHROMATOGRAPHY; CYCLODEXTRINS; HYDROXYPROPYL-BETA-CYCLODEXTRIN; PARTITION COEFFICIENTS; SHAKE-FLASK METHOD;
D O I：
10.1016/0003-2670(91)85101-W
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A shake-flask method is presented which uses a three-phase model to measure octanol-water and cyclodextrin-water partition coefficients. Equations are derived which account for all equilibria and which relate the cyclodextrin-water partition coefficient to the formation constant for a cyclodextrin-solute complex. The partition coefficients of three aromatic solutes were determined and these values compared well with previously published partition coefficients. Solute concentration was determined using liquid chromatography.
引用
收藏
页码：157 / 162
页数：6
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