THROMBOMODULIN - BIOLOGY AND POTENTIAL CARDIOVASCULAR APPLICATIONS

被引：43

作者：

DITTMAN, WA ^{[1
]}

机构：

[1] DUKE UNIV,SCH MED,DURHAM,NC 27705

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 1991年 / 1卷 / 08期

关键词：

D O I：

10.1016/1050-1738(91)90070-U

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thrombomodulin on endothelial surfaces is the major cofactor for the activation of the anticoagulant protein C by thrombin. Recent studies of the structure and regulation of thrombomodulin provide important clues as to its mechanism of action. These studies should enable the rational use of thrombomodulin as a therapeutic agent to inhibit coagulation either by infusion of thrombomodulin or its derivatives, or by pharmacologic alteration of cellular levels.

引用

页码：331 / 336

页数：6

共 43 条

[1] HETEROGENEOUS REGULATION OF CONSTITUTIVE THROMBOMODULIN OR INDUCIBLE TISSUE-FACTOR ACTIVITIES ON THE SURFACE OF HUMAN SAPHENOUS-VEIN ENDOTHELIAL-CELLS IN CULTURE FOLLOWING STIMULATION BY INTERLEUKIN-1, TUMOR-NECROSIS-FACTOR, THROMBIN OR PHORBOL ESTER [J].