PROTECTION BY A POLYVALENT VACCINE AGAINST CHALLENGE INFECTION AND PYELONEPHRITIS

被引：20

作者：

KRUZE, D ^{[1
]}

BIRO, K ^{[1
]}

HOLZBECHER, K ^{[1
]}

ANDRIAL, M ^{[1
]}

BOSSART, W ^{[1
]}

机构：

[1] SOLCO BASLE LTD,DEPT MICROBIOL,BASEL,SWITZERLAND

来源：

UROLOGICAL RESEARCH | 1992年 / 20卷 / 02期

关键词：

IMMUNIZATION; EXPERIMENTAL PYELONEPHRITIS; PROTECTION AGAINST UTI; ESCHERICHIA-COLI; KLEBSIELLA; PROTEUS VACCINE;

D O I：

10.1007/BF00296534

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The protective effect of immunization with a polyvalent vaccine (Solco Urovac) was studied in the mouse and the rat. The i.m. immunization increased the resistance of mice to challenge infection with all homologous strains of bacteria. The LD50 values for E. coli, Proteus mirabilis and Streptococcus were 3.5-4.5 times and that of Klebsiella as much as 600 times that in nonimmunized mice. Protection against challenge with heterologous E. coli was also achieved and persisted for about 20 weeks. Immunization with the vaccine also provided marked protection against pyelonephritis in rats. Kidneys with abscesses were seen only one-third as often as in controls, and the size of the individual abscesses was substantially smaller in the vaccinated animals. Based on the quantity of bacteria in the kidneys it was postulated that the vaccination increased the clearance of bacteria.

引用

页码：177 / 181

页数：5

共 16 条

[1]

AHLSTEDT S, 1983, PROG ALLERGY, V33, P236

[2]

Asscher AW., 1980, CHALLENGE URINARY TR

[3]

BRAUDE AI, 1961, B NEW YORK ACAD MED, V37, P448

[4]

BROOKS SJD, 1974, AM J PATHOL, V74, P359