Decreased expression of calcium-sensing receptor and parafibromin in secondary hyperparathyroidism with an abnormal whole PTH/intact PTH ratio

被引：3
|
作者：
Yamada, Shunsuke [1 ,2 ]
Tokumoto, Masanori [2 ]
Taniguchi, Masatomo [1 ]
Kitada, Hidehisa [3 ]
Tsuruya, Kazuhiko [1 ,4 ]
Kitazono, Takanari [1 ]
机构：
[1] Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka, Japan
[2] Fukuoka Dent Coll, Div Internal Med, Fukuoka, Japan
[3] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Oncol, Fukuoka, Japan
[4] Kyushu Univ, Grad Sch Med Sci, Dept Integrated Therapy Chron Kidney Dis, Fukuoka, Japan
来源：
CLINICAL KIDNEY JOURNAL | 2013年 / 6卷 / 04期
关键词：
calcium-sensing receptor; N-terminus PTH; parafibromin; secondary hyperparathyroidism;
D O I：
10.1093/ckj/sft061
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
A 34-year-old female hemodialysis patient with an abnormal whole parathyroid hormone (PTH)/intact PTH ratio (ratio = 1.14) underwent parathyroidectomy for advanced secondary hyperparathyroidism. The abnormal PTH ratio indicated a relative increase in the serum N-terminus PTH, a new molecular form of PTH. The abnormal ratio normalized immediately after the largest parathyroid gland (PTG) was removed, proving the largest PTG as causative. An immunohistochemical analysis revealed extremely decreased expression of the calcium-sensing receptor and parafibromin in the largest PTG in comparison with the other PTGs. This case indicated the possible involvement of decreased calcium-sensing receptor and parafibromin signaling in the development of the abnormal PTH ratio.
引用
收藏
页码：429 / 432
页数：4
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