SYNTHESIS AND BIOLOGICAL SIGNIFICANCES OF 1, 2, 4-TRIAZOLE AND ITS DERIVATIVES: A REVIEW

被引：142
作者：
Saini, Mukhtyar S. [1 ]
Dwivedi, Jaya [2 ]
机构：
[1] Govt GM Sci Coll, Dept Chem, Jammu 180001, Jammu & Kashmir, India
[2] Banasthali Univ, Dept Chem, Jaipur 304022, Rajasthan, India
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2013年 / 4卷 / 08期
关键词：
Triazole; Heterocyclic; Antifungal; Anticancer Activity; Anti-Inflammatory Activity; Antiviral; Anticonvulsant Activity;
D O I：
10.13040/IJPSR.0975-8232.4(8).2866-79
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In the last few decades, to synthesize the different new heterocyclic compounds along their derivatives which were evaluated for their biological activities as antimicrobial, antiviral, antitumor, anticonvulsant, antifungal, the triazole moiety seems to be very small but in the biological profile has attracted the attention of many researchers to explore this skeleton to its multiple potential against several activities. In this review we provides a brief response of the medicinal chemistry of 1, 2, 4-triazole and its derivatives. A literature survey of procedures for the preparation of 1, 2, 4-triazole and 1, 2, 3-triazoles is presented by generalized synthetic method.
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页码：2866 / 2879
页数：14
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