INTERLEUKIN-2 RECEPTOR GAMMA-CHAIN - A FUNCTIONAL COMPONENT OF THE INTERLEUKIN-4 RECEPTOR

被引：803
作者：
RUSSELL, SM
KEEGAN, AD
HARADA, N
NAKAMURA, Y
NOGUCHI, M
LELAND, P
FRIEDMANN, MC
MIYAJIMA, A
PURI, RK
PAUL, WE
LEONARD, WJ
机构：
[1] NHLBI,PULM & MOLEC IMMUNOL SECT,BETHESDA,MD 20892
[2] NIAID,IMMUNOL LAB,BETHESDA,MD 20892
[3] DNAX RES INST MOLEC & CELLULAR BIOL INC,PALO ALTO,CA 94304
[4] US FDA,CTR BIOL EVALUAT & RES,DIV CELLULAR & GENE THERAPIES,BETHESDA,MD 20892
来源：
SCIENCE | 1993年 / 262卷 / 5141期
关键词：
D O I：
10.1126/science.8266078
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The interleukin-2 (IL-2) receptor gamma chain (IL-2Rgamma) is an essential component of high- and intermediate-affinity IL-2 receptors. IL-2Rgamma was demonstrated to be a component of the IL-4 receptor on the basis of chemical cross-linking data, the ability of IL-2Rgamma to augment IL-4 binding affinity, and the requirement for IL-2Rgamma in IL-4-mediated phosphorylation of insulin receptor substrate-1. The observation that IL-2Rgamma is a functional component of the IL-4 receptor, together with the finding that IL-2Rgamma associates with the IL-7 receptor, begins to elucidate why deficiency of this common gamma chain (gamma(c)) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.
引用
收藏
页码：1880 / 1883
页数：4
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