Effects of vitamins C and D in type 2 diabetes mellitus

被引：21
作者：
Christie-David, Darshika J. [1 ,2 ]
Girgis, Christian M. [2 ,3 ,4 ]
Gunton, Jenny E. [1 ,2 ,3 ,4 ]
机构：
[1] Westmead Hosp, Dept Endocrinol & Diabet, Sydney, NSW, Australia
[2] Univ Sydney, Fac Med, Sydney, NSW, Australia
[3] Westmead Millennium Inst, 176 Hawkesbury Rd, Sydney, NSW 2145, Australia
[4] Garvan Inst Med Res, Sydney, NSW, Australia
来源：
NUTRITION AND DIETARY SUPPLEMENTS | 2015年 / 7卷
基金：
英国医学研究理事会;
关键词：
glucose homeostasis; diabetes; insulin resistance; vitamin C; vitamin D;
D O I：
10.2147/NDS.S52022
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Scurvy and rickets are largely considered historical diseases in developed countries. However, deficiencies in vitamins C and D are re-emerging due to increased consumption of processed foods and reduced fresh foods in the Western diet, as well as to an indoor sedentary lifestyle away from sun exposure. These dietary and lifestyle factors also predispose one to diabetes and metabolic syndrome. Our understanding of the potential roles of vitamin C (an antioxidant) and vitamin D (a biologically active hormone) in disease is increasing. In this review, we present observational, interventional, and mechanistic studies that examine the potential links between vitamins C and D in reversing defects in glucose homeostasis and the prevention of type 2 diabetes. Studies suggest an association between vitamin C deficiency and diabetes. An association between vitamin D and insulin resistance has been well described; however, the role of vitamin C and D supplementation in diabetes and its prevention requires further controlled trials.
引用
收藏
页码：21 / 28
页数：8
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