PARAOXON BLOCK OF CHLORIDE CONDUCTANCE IN CELL R2 OF APLYSIA-CALIFORNICA

被引：8

作者：

FILBERT, MG ^{[1
]}

APLAND, JP ^{[1
]}

PETRALI, JP ^{[1
]}

ADLER, M ^{[1
]}

机构：

[1] USA,MED RES INST CHEM DEF,COMPARAT PATHOL BRANCH,ABERDEEN PROVING GROUND,MD 21010

来源：

BRAIN RESEARCH BULLETIN | 1992年 / 28卷 / 03期

关键词：

APLYSIA-CALIFORNICA; CELL R2; PARAOXON; ACETYLCHOLINE; GAMMA-AMINOBUTYRIC ACID; ACETYLCHOLINESTERASE; CHLORIDE CHANNELS; VOLTAGE CLAMP;

D O I：

10.1016/0361-9230(92)90049-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the presence of paraoxon, the amplitudes of chloride currents activated by acetylcholine (ACh) or gamma-aminobutyric acid (GABA) were reduced in cell R2 of Aplysia californica. IC50 values were 12 and 9.7-mu-M for ACh and GABA responses, respectively. Paraoxon did not affect resting membrane potential, input resistance, or chloride reversal potential. Both the slopes and maxima of ACh and GABA concentration-response curves were reduced by paraoxon, suggesting that paraoxon antagonism of these responses is not competitive. The antagonism of ACh and GABA responses by paraoxon was not related to inhibition of acetylcholinesterase.

引用

页码：473 / 477

页数：5

共 24 条

[1]

BARNES EM, 1987, ADA182134 DEF TECHN

[2]

DIXON M, 1979, ENZYMES, P96

[3]

ENDRES W, 1989, J PHARMACOL EXP THER, V251, P1181

[4] MORPHOLOGICAL AND FUNCTIONAL PROPERTIES OF IDENTIFIED NEURONS IN ABDOMINAL GANGLION OF APLYSIA CALIFORNICA [J].

FRAZIER, WT ;

KANDEL, ER ;

KUPFERMANN, I ;

WAZIRI, R ;

COGGESHALL, RE .

JOURNAL OF NEUROPHYSIOLOGY, 1967, 30 (06) :1288-+

[5]

Heath D. F., 1961, ORGANOPHOSPHORUS POI

[6]

HENDERSON JR, 1967, STAIN TECHNOL, V42, P101

[7] ELECTROPHYSIOLOGICAL EFFECTS OF PARAOXON ON THE GIANT INTERNEURONS IN THE AMERICAN COCKROACH, PERIPLANETA-AMERICANA [J].

HEPPNER, TJ ;

DREWES, CD ;

COATS, JR .

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 1987, 28 (01) :57-66

[8] IONIC MECHANISMS OF A 2-COMPONENT CHOLINERGIC INHIBITION IN APLYSIA NEURONS [J].

KEHOE, J .

JOURNAL OF PHYSIOLOGY-LONDON, 1972, 225 (01) :85-&

[9]

KOELLE GB, 1949, P SOC EXP BIOL MED, V106, P622

[10]

KOELLE GB, 1963, HANDBUCH EXPERIMENTE, V15, P187

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