DOWN-REGULATION OF KE-6, A NOVEL GENE ENCODED WITHIN THE MAJOR HISTOCOMPATIBILITY COMPLEX, IN MURINE POLYCYSTIC KIDNEY-DISEASE

被引：43
作者：
AZIZ, N
MAXWELL, MM
STJACQUES, B
BRENNER, BM
机构：
[1] HARVARD UNIV,SCH MED,HARVARD CTR STUDY KIDNEY DIS,BOSTON,MA 02115
[2] MIT,WHITEHEAD INST BIOMED RES,CAMBRIDGE,MA 02142
[3] MIT,DEPT BIOL,CAMBRIDGE,MA 02142
来源：
MOLECULAR AND CELLULAR BIOLOGY | 1993年 / 13卷 / 03期
关键词：
D O I：
10.1128/MCB.13.3.1847
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Polycystic kidney disease (PKD) is characterized by progressive enlargement of the kidneys due to numerous expanding cysts ultimately leading to renal failure. We have identified a gene, Ke 6, located within the H-2K/t(w5) region on mouse chromosome 17, which is downregulated in two distinct murine models of heritable PKD. Ke 6 is a member of the short-chain alcohol dehydrogenase family and possesses remarkable amino acid sequence conservation with several bacterial proteins with oxidoreductase function. The Ke 6 gene gives rise to two transcripts-a 1-kb Ke 6a mRNA which is abundant in kidney and liver tissue and a 1.4-kb Ke 6b mRNA which is found at a moderate level in spleen tissue. We report here the complete nucleotide sequence of Ke 6a cDNA and the expression of the Ke 6 gene in murine models of PKD. The Ke 6 gene may be intimately involved in the manifestation of these cystic kidney diseases.
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页码：1847 / 1853
页数：7
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