IDENTIFICATION OF GENETIC-MARKERS FLANKING THE LOCUS FOR MATURITY-ONSET DIABETES OF THE YOUNG ON HUMAN-CHROMOSOME 20

被引：37

作者：

BOWDEN, DW

GRAVIUS, TC

AKOTS, G

FAJANS, SS

机构：

[1] COLLABORAT RES INC,DEPT HUMAN GENET,WALTHAM,MA

[2] UNIV MICHIGAN,MED CTR,DEPT INTERNAL MED,DIV ENDOCRINOL & METAB,ANN ARBOR,MI 48109

来源：

DIABETES | 1992年 / 41卷 / 01期

关键词：

D O I：

10.2337/diabetes.41.1.88

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A systematic search for genetic linkage with maturity-onset diabetes of the young (MODY) as expressed in the R.-W. pedigree has been carried out. Evidence for linkage was found with restriction-fragment-length polymorphism loci that map to human chromosome 20. Two-point linkage analysis with CRI-L1214 (D20S16) and MODY gave a log of the odds (lod) score of 4.16 at Kelvin = 0.08. Multipoint linkage analysis with nine restriction-fragment-length polymorphism loci resulted in a lod score of 4.81 with the MODY locus in an approximately 20-cM region bounded by D20S16 and D20S14-D20S18. Examination of the pattern of MODY segregation suggests that additional factors, possibly genetic, could be involved in the age of onset of the disease.

引用

页码：88 / 92

页数：5

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