THE ANTISTEROID RU486 - ITS CELLULAR AND MOLECULAR-MODE OF ACTION

被引：73
作者：
BAULIEU, EE
机构：
[1] Hormone Laboratory, INSERM U33
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1991年 / 2卷 / 06期
关键词：
D O I：
10.1016/1043-2760(91)90030-Q
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
RU486 is a very powerful antisteroid hormone compound, with antiprogestin and antiglucocorticosteroid clinical applications. High-affinity binding to the receptor ligand-binding domain results in essentially antagonistic function; however, some agonistlike effects have been observed. This review discusses the implications of recent discoveries concerning hsp90 (heat-shock protein M(r) approximately 90,000)-receptor interaction, receptor-DNA binding, and the involvement of transcription factors in the mechanism of action of RU486.
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页码：233 / 239
页数：7
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