Clinical and Pathological Implications of Concurrent Autoimmune Thyroid Disorders and Papillary Thyroid Cancer

被引：43

作者：

Cunha, L. L. ^{[1
]}

Ferreira, R. C. ^{[1
]}

Marcello, M. A. ^{[1
]}

Vassallo, J. ^{[2
]}

Ward, L. S. ^{[1
]}

机构：

[1] Univ Campinas FCM Unicamp, Fac Med Sci, Lab Canc Mol Genet, 126 Tessalia Vieira Camargo St,Cidade Univ, BR-13083970 Sao Paulo, SP, Brazil

[2] Univ Campinas Unicamp, Fac Med Sci, Ciped, Lab Mol Pathol, BR-13083970 Sao Paulo, SP, Brazil

来源：

JOURNAL OF THYROID RESEARCH | 2011年 / 2011卷

关键词：

D O I：

10.4061/2011/387062

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cooccurrences of chronic lymphocytic thyroiditis (CLT) and thyroid cancer (DTC) have been repeatedly reported. Both CLT and DTC, mainly papillary thyroid carcinoma (PTC), share some epidemiological and molecular features. In fact, thyroid lymphocytic inflammatory reaction has been observed in association with PTC at variable frequency, although the precise relationship between the two diseases is still debated. It also remains a matter of debate whether the association with a CLT or even an autoimmune disorder could influence the prognosis of PTC. A better understanding about clinical implications of autoimmunity in concurrent thyroid cancer could raise new insights of thyroid cancer immunotherapy. In addition, elucidating the molecular mechanisms involved in autoimmune disease and concurrent cancer allowed us to identify new therapeutic strategies against thyroid cancer. The objective of this article was to review recent literature on the association of these disorders and its potential significance.

引用

页数：13

共 164 条

[1] Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma [J].

Akulevich, Natallia M. ;

Saenko, Vladimir A. ;

Rogounovitch, Tatiana I. ;

Drozd, Valentina M. ;

Lushnikov, Eugeny F. ;

Ivanov, Victor K. ;

Mitsutake, Norisato ;

Kominami, Ryo ;

Yamashita, Shunichi .

[2]

American Cancer Society, CANC FACTS FIG 2015

[3]

[Anonymous], 2004, DRUG DISCOVERY TODAY

[4] The relationship between multiple intrathyroidal involvement in papillary thyroid carcinoma and chronic non-specific thyroiditis [J].

Asanuma, K ;

Sugenoya, A ;

Kasuga, Y ;

Itoh, N ;

Kobayashi, S ;

Amano, J .

CANCER LETTERS, 1998, 122 (1-2) :177-180

[5] Solid Cell Nests in Hashimoto's Thyroiditis Sharing Features with Papillary Thyroid Microcarcinoma [J].

Asioli, Sofia ;

Erickson, Lori A. ;

Lloyd, Ricardo V. .

ENDOCRINE PATHOLOGY, 2009, 20 (04) :197-203

[6] Inflammation and cancer: back to Virchow? [J].

Balkwill, F ;

Mantovani, A .

LANCET, 2001, 357 (9255) :539-545

[7] Toll-like receptor signaling pathways [J].

Barton, GM ;

Medzhitov, R .

SCIENCE, 2003, 300 (5625) :1524-1525

[8]

BECKNER ME, 1990, ARCH PATHOL LAB MED, V114, P1049

[9] INCREASED AGGRESSIVENESS OF THYROID-CANCER IN PATIENTS WITH GRAVES-DISEASE [J].

BELFIORE, A ;

GAROFALO, MR ;

GIUFFRIDA, D ;

RUNELLO, F ;

FILETTI, S ;

FIUMARA, A ;

IPPOLITO, O ;

VIGNERI, R .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1990, 70 (04) :830-835

[10] Graves' disease, thyroid nodules and thyroid cancer [J].

Belfiore, A ;

Russo, D ;

Vigneri, R ;

Filetti, S .

CLINICAL ENDOCRINOLOGY, 2001, 55 (06) :711-718

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