MORPHOFUNCTIONAL CHARACTERISTICS OF METRONIDAZOLE-RESISTANT TRICHOMONAS-VAGINALIS STRAIN

被引：0
作者：
DMITRIYEV, GA
BRAGHINA, YY
KISINA, VI
VAKHNINA, TY
ABDUMALIKOV, RA
机构：
来源：
VESTNIK DERMATOLOGII I VENEROLOGII | 1994年 / 04期
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中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Trichomonas vaginalis strain isolated from a female patient ineffectively treated with metronidazole was studied. Metronidazole sensitivity was assessed by serial dilutions method and was found to be 30 mug/ml, whereas the reference strain sensitivity was 1 mug/ml. Electronmicroscopic examination has revealed changed structure of protozoan hydrogenosomes. Analysis of the morphologic findings and their comparison with biochemical findings of other authors permitted the authors to suppose that development of metronidazole resistance is explained by disturbed metabolic reactions running in the hydrogenosomes.
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页码：12 / 15
页数：4
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