ANTAGONISM OF MEDETOMIDINE SEDATION BY ATIPAMEZOLE IN PIGS

被引：16

作者：

NISHIMURA, R ^{[1
]}

KIM, H ^{[1
]}

MATSUNAGA, S ^{[1
]}

SAKAGUCHI, M ^{[1
]}

SASAKI, N ^{[1
]}

TAMURA, H ^{[1
]}

TAKEUCHI, A ^{[1
]}

机构：

[1] TEIKYO UNIV,CTR LAB ANIM,ITABASHI KU,TOKYO 173,JAPAN

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 1992年 / 54卷 / 06期

关键词：

ATIPAMEZOLE; MEDETOMIDINE; PIG;

D O I：

10.1292/jvms.54.1237

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The efficacy of atipamezole as a medetomidine antagonist was evaluated in pigs. The atipamezole doses (intramuscularly) were 80, 160, 320 and 480 mug/kg of body weight, which were one, two, four and six times higher than the preceding medetomidine dose (80 mug/kg, intramuscularly). Atipamezole effectively reversed medetomidine-induced sedation, and the optimal action was seen at doses of 160 and 320 mug/kg. Recovery from sedation was quick and smooth, and adverse effects such as hyperactivity or tachycardia were minimal with either dose.

引用

页码：1237 / 1240

页数：4

共 6 条

[1]

GOLDBERG MR, 1983, PHARMACOL REV, V35, P143

[2] SEDATIVE EFFECTS OF MEDETOMIDINE IN PIGS [J].