A clinical perspective on the role of chronic inflammation in gastrointestinal cancer

被引：22
作者：
Rasch, Sebastian [1 ]
Algul, Hana [1 ]
机构：
[1] Tech Univ Munich, Klinikum Rechts Isar, Med Klin & Poliklin 2, Munich, Germany
来源：
CLINICAL AND EXPERIMENTAL GASTROENTEROLOGY | 2014年 / 7卷
关键词：
inflammation; immune response; carcinogenesis; gastrointestinal cancer; risk factor;
D O I：
10.2147/CEG.S43457
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Chronic inflammation has been identified as an important risk factor for the development of malignancy, and knowledge about its molecular and cellular mechanisms is increasing. Several chronic inflammatory diseases of the gastrointestinal tract are important as risk factors for malignancy and have been studied in detail. In this review, we summarize important molecular mechanisms in chronic inflammation and highlight established and potential links between chronic inflammation and gastrointestinal cancer. In addition, we present the role of chronic inflammation in numerous tumors within the gastrointestinal tract as well as the relevant pathways or epidemiologic observations linking the pathogenesis of these tumors to inflammation.
引用
收藏
页码：261 / 272
页数：12
相关论文
共 155 条
[61]   Epidemiology and Surveillance of Hepatocellular Carcinoma [J].
Kim, Do Young ;
Han, Kwang-Hyub .
LIVER CANCER, 2012, 1 (01) :2-14
[62]   NF-κB and IKK as therapeutic targets in cancer [J].
Kim, HJ ;
Hawke, N ;
Baldwin, AS .
CELL DEATH AND DIFFERENTIATION, 2006, 13 (05) :738-747
[63]   Helicobacter pylori in the pathogenesis of gastric cancer and gastric lymphoma [J].
Kim, Sung Soo ;
Ruiz, Victoria E. ;
Carroll, Jaqueline D. ;
Moss, Steven F. .
CANCER LETTERS, 2011, 305 (02) :228-238
[64]   Interleukin-6 Mediates Epithelial-Stromal Interactions and Promotes Gastric Tumorigenesis [J].
Kinoshita, Hiroto ;
Hirata, Yoshihiro ;
Nakagawa, Hayato ;
Sakamoto, Kei ;
Hayakawa, Yoku ;
Takahashi, Ryota ;
Nakata, Wachiko ;
Sakitani, Kosuke ;
Serizawa, Takako ;
Hikiba, Yohko ;
Akanuma, Masao ;
Shibata, Wataru ;
Maeda, Shin ;
Koike, Kazuhiko .
PLOS ONE, 2013, 8 (04)
[65]  
Kleeff J, 1999, INT J CANCER, V81, P650, DOI 10.1002/(SICI)1097-0215(19990517)81:4<650::AID-IJC23>3.0.CO
[66]  
2-#
[67]   Risk factors for pancreatic cancer: underlying mechanisms and potential targets [J].
Kolodecik, Thomas ;
Shugrue, Christine ;
Ashat, Munish ;
Thrower, Edwin C. .
FRONTIERS IN PHYSIOLOGY, 2014, 4
[68]   Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells [J].
Kong, D. ;
Piao, Y-S ;
Yamashita, S. ;
Oshima, H. ;
Oguma, K. ;
Fushida, S. ;
Fujimura, T. ;
Minamoto, T. ;
Seno, H. ;
Yamada, Y. ;
Satou, K. ;
Ushijima, T. ;
Ishikawa, T-O ;
Oshima, M. .
ONCOGENE, 2012, 31 (35) :3949-3960
[69]   HIF-1α induces genetic instability by transcriptionally downregulating MutSα expression [J].
Koshiji, M ;
To, KKW ;
Hammer, S ;
Kumamoto, K ;
Harris, AL ;
Modrich, P ;
Huang, LE .
MOLECULAR CELL, 2005, 17 (06) :793-803
[70]   Infection as a risk factor for gallbladder cancer [J].
Kumar, Sandeep ;
Kumar, Shailendra ;
Kumar, Surender .
JOURNAL OF SURGICAL ONCOLOGY, 2006, 93 (08) :633-639
234567891011