HYDROGEL DELIVERY SYSTEMS FOR VAGINAL AND ORAL APPLICATIONS - FORMULATION AND BIOLOGICAL CONSIDERATIONS

被引：67
作者：
KNUTH, K
AMIJI, M
ROBINSON, JR
机构：
[1] UNIV WISCONSIN, SCH PHARM, 425 N CHARTER ST, MADISON, WI 53706 USA
[2] COLUMBIA RES LABS, MADISON, WI USA
[3] NORTHEASTERN UNIV, COLL PHARM & HLTH SCI, BOSTON, MA 02115 USA
来源：
ADVANCED DRUG DELIVERY REVIEWS | 1993年 / 11卷 / 1-2期
关键词：
HYDROGELS; DRUG DELIVERY SYSTEM; VAGINAL; ORAL CAVITY; GASTROINTESTINAL; COLON; RECTAL;
D O I：
10.1016/0169-409X(93)90030-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Hydrophilic polymer gels (hydrogels) exhibit a range of physical, chemical, and biological properties which makes them attractive as drug delivery systems. Such systems are biocompatible and can be formulated to give controlled, pulsed, and triggered drug release profiles in a variety of tissues. This review will focus on delivery to the vaginal and oral areas including the oral cavity, stomach, small intestine, colon and rectum. Careful attention to the unique physiology of each area allows the development of drug formulations capable of providing the desired release profile, minimum irritation, and fewest side effects.
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收藏
页码：137 / 167
页数：31
相关论文
共 75 条
[1]  
APRRASHID A, 1990, Patent No. 2230441
[2]  
AREF I, 1978, HUMAN REPRODUCTIVE M, V2, P179
[3]  
BACHMANN GA, 1992, CLINPRAC SEX, V7, P1
[4]  
Bergh PA, 1988, GYNECOLOGIST OLDER P, P299
[5]  
BISHOP EH, 1964, OBSTET GYNECOL, V24, P266
[6]  
BLOCK LH, 1990, REMINGTONS PHARM SCI, P1596
[7]  
BOWERSOCK TL, 1992, P INT S RELEASE BIOA, V19, P80
[8]   HYDROGELS FOR SITE-SPECIFIC ORAL-DRUG DELIVERY - SYNTHESIS AND CHARACTERIZATION [J].
BRONDSTED, H ;
KOPECEK, J .
BIOMATERIALS, 1991, 12 (06) :584-592
[9]   A LIGNOCAINE PATCH FOR DENTAL ANALGESIA SAFETY AND EARLY PHARMACOLOGY [J].
BROOK, IM ;
TUCKER, GT ;
TUCKLEY, EC ;
BOYES, RN .
JOURNAL OF CONTROLLED RELEASE, 1989, 10 (02) :183-188
[10]  
BROWN WJ, 1978, HUMAN REPROD MED HUM, V2, P407
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