Gingival leukemic infiltration as the first manifestation of acute myeloid leukemia

被引:12
作者
Fernandes, Karin Sa [1 ,2 ]
Gallottini, Marina [1 ]
Castro, Talita [1 ]
Amato, Mauricio Flaminio [3 ]
Lago, Juvani Saturno [1 ]
Braz-Silva, Paulo Henrique [1 ,4 ]
机构
[1] Univ Sao Paulo, Sch Dent, Dept Stomatol, Sao Paulo, Brazil
[2] Univ Sao Paulo City, Dept Orthodont & Radiol, UNICID, Sao Paulo, Brazil
[3] Peruibes Dent Specialty Ctr, Sao Paulo, Brazil
[4] Univ Sao Paulo, Inst Trop Med Sao Paulo, Lab Virol, Sao Paulo, Brazil
关键词
acute myeloid leukemia; gingival enlargement; gingival leukemic infiltration; gingival overgrowth; leukemia;
D O I
10.1111/scd.12283
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Leukemic infiltration of the gingival tissue associated or not with gingival enlargement may be the first manifestation of acute leukemia, despite being rarely reported in the literature. A 10-year-old female patient presented with a 1-month history of an asymptomatic, firm, and pinkish-red generalized gingival overgrowth. There was no bone resorption. Incisional biopsy of the gingival tissue was performed, with histopathological examination revealing a diffuse and hypercellular infiltration of monocytoid cells. The patient was referred to a hematologist and underwent a bone marrow biopsy, which led to a conclusive diagnosis of acute myeloid leukemia. The patient was treated with chemotherapy and we observed regression of gingival enlargement after 4 weeks from the initial therapy.
引用
收藏
页码:160 / 162
页数:3
相关论文
共 19 条
[1]   Leukaemic infiltration of the mandible in a young girl [J].
Benson, Rachael E. ;
Rodd, Helen D. ;
North, Sarah ;
Loescher, Alison R. ;
Farthing, Paula M. ;
Payne, Martin .
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY, 2007, 17 (02) :145-150
[2]  
BERKHEISER SW, 1957, CANCER, V10, P606, DOI 10.1002/1097-0142(195705/06)10:3<606::AID-CNCR2820100328>3.0.CO
[3]  
2-S
[4]  
Cooper C L, 2000, J Can Dent Assoc, V66, P78
[5]   Gingival leukemic infiltration as the first manifestation of acute myeloid leukemia [J].
da Silva Santos, Paulo Sergio ;
Fontes, Alexandra ;
de Andrade, Flavio ;
Orsini Machado de Sousa, Suzana Cantanhede .
OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2010, 143 (03) :465-466
[6]  
DEMIRER S., 2007, EUR J DENT, V4, P111
[7]   Manifestation of acute monocytic leukemia in the oral cavity: a case report [J].
Fatahzadeh, Mahnaz ;
Krakow, A. Michael .
SPECIAL CARE IN DENTISTRY, 2008, 28 (05) :190-194
[8]  
Francisconi Carolina Favaro, 2016, Asian Pac J Cancer Prev, V17, P911
[9]   A study of the acute leukoses [J].
Kaufmann, J ;
Lowenstein, L .
ANNALS OF INTERNAL MEDICINE, 1940, 14 (05) :903-915
[10]   Leukemic gingival infiltration [J].
Mani, Aparna ;
Lee, David A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (03) :274-274