SYSTEMIC AND LOCAL IMMUNE-RESPONSES TO ENHANCED-POTENCY INACTIVATED POLIOVIRUS VACCINE IN PREMATURE AND TERM INFANTS

被引：37

作者：

ADENYIJONES, SCA

FADEN, H

FERDON, MB

KWONG, MS

OGRA, PL

机构：

[1] CHILDRENS HOSP BUFFALO, DIV INFECT DIS, 219 BRYANT ST, BUFFALO, NY 14222 USA

[2] THOMAS JEFFERSON UNIV, DEPT PEDIAT, DIV NEONATOL, PHILADELPHIA, PA 19107 USA

[3] SUNY BUFFALO, SCH MED, DEPT PEDIAT, DIV NEONATOL, BUFFALO, NY 14214 USA

[4] SUNY BUFFALO, SCH MED, DIV INFECT DIS, BUFFALO, NY 14214 USA

[5] UNIV TEXAS, MED BRANCH, DEPT PEDIAT, GALVESTON, TX 77550 USA

来源：

JOURNAL OF PEDIATRICS | 1992年 / 120卷 / 05期

关键词：

D O I：

10.1016/S0022-3476(05)80228-8

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Serum neutralizing, nasopharyngeal neutralizing, and IgA antibodies to polioviruses 1, 2, and 3 were detected in preterm and term infants who had received three doses of an enhanced-potency inactivated Poliovirus vaccine at 2,4, and 12 months of age. After the third dose of this vaccine, 95% or more of the infants tested had detectable serum neutralizing antibodies to polioviruses types 1, 2, and 3. Nasopharyngeal neutralizing and IgA antibodies were defected in 43% to 91% of the infants. The peak geometric mean titers of serum and nasopharyngeal antibodies against polioviruses types 1, 2, and 3 were similar for both groups. These preliminary data indicate that preterm infants are capable of mounting systemic and local immune responses to enhanced-potency inactivated poliovirus vaccine that are comparable to those made by term infants.

引用

页码：686 / 689

页数：4