COMPARATIVE-STUDIES ON BIOACCUMULATION OF PCDDS AND PCDFS IN C57BL/6 AND DBA/2 MICE TREATED WITH A MIXTURE BY ORAL-ADMINISTRATION

被引：1
|
作者：
AOZASA, O
OHTA, S
MASE, Y
MIYATA, H
机构：
[1] Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, 573-01
来源：
CHEMOSPHERE | 1995年 / 30卷 / 09期
关键词：
D O I：
10.1016/0045-6535(95)00050-I
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
To determine the cause of the extremely high accumulative potency of OCDD in human tissues, EROD activity and accumulation of 2,3,7,8-chlorine substituted PCDDs and PCDFs in liver of C57BL/6 and DEAR mice administered these chemicals orally were measured during a period of 28 days. Consequently, in both C57BL/6 mice with high EROD induction and DBA/2 mice with low EROD induction, there was no high accumulation of OCDD similar to that observed in human tissues. In addition, the C57BL/6 mice accumulated larger amounts of these chemicals in their liver than did the DBA/2 mice.
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页码：1819 / 1828
页数：10
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