A NOVEL TESTOSTERONE 5-ALPHA-REDUCTASE INHIBITOR, 8',9'-DEHYDROASCOCHLORIN PRODUCED BY VERTICILLIUM SP FO-2787

被引：0

作者：

TAKAMATSU, S

RHO, MC

MASUMA, R

HAYASHI, M

KOMIYAMA, K

TANAKA, H

OMURA, S

机构：

[1] KITASATO UNIV, KITASATO INST, MINATO KU, TOKYO 108, JAPAN

[2] KITASATO UNIV, SCH PHARMACEUT SCI, MINATO KU, TOKYO 108, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1994年 / 42卷 / 04期

关键词：

MICROBIAL METABOLITE; TESTOSTERONE 5-ALPHA-REDUCTASE INHIBITOR; 8'; 9'-DEHYDROASCOCHLORIN; VERTICILLIUM; CULTURED MYCELIUM;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new testosterone Scc-reductase inhibitor, 8',9'-dehydroascochlorin, was isolated from the cultured mycelium of Verticillum sp. FO-2787. This compound (M.W.: 402, C23H27ClO4) consists of 5-chloroorcylic aldehyde and 2,3,4-trimethylcyclohexenone moieties, which are connected via a chain of (2E,4E)-3-methyl-2,4-pentadiene. The IC50 value of the new microbial metabolite for testosterone Sa-reductase activity prepared from rat prostate was 4 x 10(-4) M.

引用

页码：953 / 956

页数：4