A NOVEL TESTOSTERONE 5-ALPHA-REDUCTASE INHIBITOR, 8',9'-DEHYDROASCOCHLORIN PRODUCED BY VERTICILLIUM SP FO-2787

被引：0
|
作者：
TAKAMATSU, S
RHO, MC
MASUMA, R
HAYASHI, M
KOMIYAMA, K
TANAKA, H
OMURA, S
机构：
[1] KITASATO UNIV, KITASATO INST, MINATO KU, TOKYO 108, JAPAN
[2] KITASATO UNIV, SCH PHARMACEUT SCI, MINATO KU, TOKYO 108, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1994年 / 42卷 / 04期
关键词：
MICROBIAL METABOLITE; TESTOSTERONE 5-ALPHA-REDUCTASE INHIBITOR; 8'; 9'-DEHYDROASCOCHLORIN; VERTICILLIUM; CULTURED MYCELIUM;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new testosterone Scc-reductase inhibitor, 8',9'-dehydroascochlorin, was isolated from the cultured mycelium of Verticillum sp. FO-2787. This compound (M.W.: 402, C23H27ClO4) consists of 5-chloroorcylic aldehyde and 2,3,4-trimethylcyclohexenone moieties, which are connected via a chain of (2E,4E)-3-methyl-2,4-pentadiene. The IC50 value of the new microbial metabolite for testosterone Sa-reductase activity prepared from rat prostate was 4 x 10(-4) M.
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页码：953 / 956
页数：4
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