THE BIOADHESIVE PROPERTIES OF A TRIBLOCK COPOLYMER OF EPSILON-CAPROLACTONE AND ETHYLENE-OXIDE

被引：11

作者：

MARTINI, L ^{[1
]}

ATTWOOD, D ^{[1
]}

COLLETT, JH ^{[1
]}

DEMANUELE, A ^{[1
]}

机构：

[1] UNIV MANCHESTER,DEPT PHARM,MANCHESTER M13 9PL,LANCS,ENGLAND

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 113卷 / 02期

关键词：

BIOADHESION; BLOCK COPOLYMER; ENVIRONMENTAL SCANNING ELECTRON MICROSCOPY;

D O I：

10.1016/0378-5173(94)00202-G

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tablets produced by compression of a novel biodegradable triblock copolymer of epsilon-caprolactone (CL) and ethylene oxide (E), CL(6)E(90)CL(6), have been shown to possess bioadhesive properties. The work of adhesion, the detachment force, the fracture strength, and the modulus of elasticity were calculated from force-elongation curves measured for polymer tablets in contact with mucosal tissue from rat duodenum. Environmental scanning electron microscopy was used to investigate changes in the appearance of the tablet surface during its hydration acid also after adhesion to the mucosal tissue.

引用

页码：223 / 229

页数：7

共 50 条

[21] Poly(ethylene glycol)-poly(epsilon-caprolactone) block oligomers as injectable materials
Sosnik, A
Cohn, D
POLYMER, 2003, 44 (23) : 7033 - 7042
[22] ABSORBABLE FIBERS OF EPSILON-CAPROLACTONE GLYCOLIDE COPOLYMERS AND THEIR BIOLOGICAL PROPERTIES
SHALABY, SW
JAMIOIKOWSKI, DD
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1985, 190 (SEP): : 129 - POY
[23] LACTONE POLYMERS .8. DYNAMIC MECHANICAL-PROPERTIES OF EPSILON-CAPROLACTONE AND GAMMA-(TERT-BUTYL)-EPSILON-CAPROLACTONE COPOLYMERS
SEEFRIED, CG
KOLESKE, JV
CRITCHFIELD, FE
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 1976, 14 (11) : 2011 - 2017
[24] INCLUSION COMPOUND FORMED BETWEEN A POLY(EPSILON-CAPROLACTONE)-POLYBUTADIENE DIBLOCK COPOLYMER AND UREA
VASANTHAN, N
TONELLI, AE
NOJIMA, S
MACROMOLECULES, 1994, 27 (24) : 7220 - 7221
[25] Y-shaped biotin-conjugated poly (ethylene glycol)-poly (epsilon-caprolactone) copolymer for the targeted delivery of curcumin
Zhu, Wenxia
Song, Zhimei
Wei, Peng
Meng, Ning
Teng, Fangfang
Yang, Fengying
Liu, Na
Feng, Runliang
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2015, 443 : 1 - 7
[26] Miscible blends of polystyrene and poly(epsilon-caprolactone) with phenylacetylene carbon monoxide alternating copolymer
Chen, HL
Liaw, DJ
Tsai, JS
Shyu, JS
Yang, JM
POLYMER JOURNAL, 1996, 28 (11) : 976 - 979
[27] TETRAPHENYLPORPHYRIN-ALUMINUM COMPOUNDS AS INITIATORS FOR THE RING-OPENING POLYMERIZATION OF 2,2-DIMETHYLTRIMETHYLENE CARBONATE - SYNTHESIS OF HOMOPOLYMERS AND COPOLYMERS WITH EPSILON-CAPROLACTONE, ETHYLENE-OXIDE AND PROPYLENE-OXIDE
HOVESTADT, W
KEUL, H
HOCKER, H
POLYMER, 1992, 33 (09) : 1941 - 1948
[28] Structure and thermal/mechanical properties of poly(epsilon-caprolactone)-clay blend
Jimenez, G
Ogata, N
Kawai, H
Ogihara, T
JOURNAL OF APPLIED POLYMER SCIENCE, 1997, 64 (11) : 2211 - 2220
[29] The effect of molecular weight on the rheological and tensile properties of poly(epsilon-caprolactone)
Grosvenor, MP
Staniforth, JN
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1996, 135 (1-2) : 103 - 109
[30] SYNTHESIS OF TELECHELIC DIMETHYLSILOXANE ETHYLENE-OXIDE DIMETHYLSILOXANE TRIBLOCK COPOLYMERS
GERARD, E
GNANOU, Y
POLYMER COMMUNICATIONS, 1990, 31 (02): : 77 - 79

← 1 2 3 4 5 →