THE BIOADHESIVE PROPERTIES OF A TRIBLOCK COPOLYMER OF EPSILON-CAPROLACTONE AND ETHYLENE-OXIDE

被引：11
|
作者：
MARTINI, L [1 ]
ATTWOOD, D [1 ]
COLLETT, JH [1 ]
DEMANUELE, A [1 ]
机构：
[1] UNIV MANCHESTER,DEPT PHARM,MANCHESTER M13 9PL,LANCS,ENGLAND
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 113卷 / 02期
关键词：
BIOADHESION; BLOCK COPOLYMER; ENVIRONMENTAL SCANNING ELECTRON MICROSCOPY;
D O I：
10.1016/0378-5173(94)00202-G
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Tablets produced by compression of a novel biodegradable triblock copolymer of epsilon-caprolactone (CL) and ethylene oxide (E), CL(6)E(90)CL(6), have been shown to possess bioadhesive properties. The work of adhesion, the detachment force, the fracture strength, and the modulus of elasticity were calculated from force-elongation curves measured for polymer tablets in contact with mucosal tissue from rat duodenum. Environmental scanning electron microscopy was used to investigate changes in the appearance of the tablet surface during its hydration acid also after adhesion to the mucosal tissue.
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页码：223 / 229
页数：7
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