ENHANCEMENT OF MOTOR-NERVE REGENERATION BY NERVE GROWTH-FACTOR

被引：54
作者：
HE, CL [1 ]
CHEN, ZW [1 ]
CHEN, ZR [1 ]
机构：
[1] SHANGHAI MED UNIV,ZHONGSHAN HOSP,DEPT ORTHOPAED,SHANGHAI 200032,PEOPLES R CHINA
来源：
MICROSURGERY | 1992年 / 13卷 / 03期
关键词：
D O I：
10.1002/micr.1920130310
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
The sciatic nerves of adult Wistar rats were severed bilaterally. Each nerve was sutured into a silicone tube used as a conduit, leaving a 5 mm gap in length between the nerve ends. Nerve growth factor in a saline solution vehicle was injected into the silicone chamber on the right side and normal saline solution (control) on the left. Six weeks after surgery, electrophysiological studies were performed. The motor nerve conduction velocities (MNCV) were significantly increased in the NGF-treated nerves. In one rat, the MNCV on the NGF-treated side was 66.6 m/s, in the range of normal nerves. There was no significant difference between the two sides in the amplitudes of evoked muscle action potentials. There are apparently no reports on the effect of NGF on motor neuron regeneration in vitro. In this study, NGF was found to enhance motor nerve regeneration.
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页码：151 / 154
页数：4
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