THE DYNAMICS OF PROTEIN-PHOSPHORYLATION IN BACTERIAL CHEMOTAXIS

被引:165
作者
BORKOVICH, KA
SIMON, MI
机构
[1] Division of Biology California Institute of Technology Pasadena
关键词
D O I
10.1016/0092-8674(90)90429-I
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The chemotaxis signal transduction pathway allows bacteria to respond to changes in concentration of specific chemicals (ligands) by modulating their swimming behavior. The pathway includes ligand binding receptors, and the CheA, CheY, CheW, and CheZ proteins. We showed previously that phosphorylation of CheY is activated in reactions containing receptor, CheW, CheA, and CheY. Here we demonstrate that this activation signal results from accelerated autophosphorylation of the CheA kinase. Evidence for a second signal transmitted by a ligand-bound receptor, which corresponds to inhibition of CheA autophosphorylation, is also presented. We postulate that CheA can exist in three forms: a "closed" form in the absence of receptor and CheW; an "open" form that results from activation of CheA by receptor and CheW; and a "sequestered" form in reactions containing ligand-bound receptor and CheW. The system's dynamics depends on the relative distribution of CheA among these three forms at any time.
引用
收藏
页码:1339 / 1348
页数:10
相关论文
共 45 条
[1]   DECISION-MAKING IN BACTERIA - CHEMOTACTIC RESPONSE OF ESCHERICHIA-COLI TO CONFLICTING STIMULI [J].
ADLER, J ;
TSO, WW .
SCIENCE, 1974, 184 (4143) :1293-1294
[2]   TRANSMEMBRANE SIGNALING BY BACTERIAL CHEMORECEPTORS - ESCHERICHIA-COLI TRANSDUCERS WITH LOCKED SIGNAL OUTPUT [J].
AMES, P ;
PARKINSON, JS .
CELL, 1988, 55 (05) :817-826
[3]   TRANSIENT-RESPONSE TO CHEMOTACTIC STIMULI IN ESCHERICHIA-COLI [J].
BERG, HC ;
TEDESCO, PM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (08) :3235-3239
[4]   TRANSMEMBRANE SIGNAL TRANSDUCTION IN BACTERIAL CHEMOTAXIS INVOLVES LIGAND-DEPENDENT ACTIVATION OF PHOSPHATE GROUP TRANSFER [J].
BORKOVICH, KA ;
KAPLAN, N ;
HESS, JF ;
SIMON, MI .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (04) :1208-1212
[5]   CONSERVED ASPARTATE RESIDUES AND PHOSPHORYLATION IN SIGNAL TRANSDUCTION BY THE CHEMOTAXIS PROTEIN CHEY [J].
BOURRET, RB ;
HESS, JF ;
SIMON, MI .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (01) :41-45
[6]  
BOURRET RB, 1989, J BIOL CHEM, V264, P7085
[7]  
CASEY PJ, 1988, J BIOL CHEM, V263, P2577
[8]  
GILMAN AG, 1987, ANNU REV BIOCHEM, V56, P615, DOI 10.1146/annurev.bi.56.070187.003151
[9]   SENSORY TRANSDUCTION IN ESCHERICHIA-COLI - ROLE OF A PROTEIN METHYLATION REACTION IN SENSORY ADAPTATION [J].
GOY, MF ;
SPRINGER, MS ;
ADLER, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (11) :4964-4968
[10]   PHOSPHORYLATION OF 3 PROTEINS IN THE SIGNALING PATHWAY OF BACTERIAL CHEMOTAXIS [J].
HESS, JF ;
OOSAWA, K ;
KAPLAN, N ;
SIMON, MI .
CELL, 1988, 53 (01) :79-87