SYNTHESIS OF SOME MIMICS OF NUCLEOSIDE TRIPHOSPHATES

被引:39
作者
COE, DM
HILPERT, H
NOBLE, SA
PEEL, MR
ROBERTS, SM
STORER, R
机构
[1] GLAXO GRP RES LTD,DEPT MED CHEM,GREENFORD UB6 0HE,MIDDX,ENGLAND
[2] GLAXO INC,DEPT CHEM,RES TRIANGLE PK,NC
关键词
D O I
10.1039/c39910000312
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The nucleotide analogues 10, 13, 14 and 20 have been synthesised; the latter phosphonate was converted into the diphosphoryl-phosphonate 21 and this compound was shown to be a potent inhibitor of HIV-coded reverse transcriptase.
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页码:312 / 314
页数:3
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