BUTYRATE METABOLISM IN THE TERMINAL ILEAL MUCOSA OF PATIENTS WITH ULCERATIVE-COLITIS

被引：52

作者：

CHAPMAN, MAS ^{[1
]}

GRAHN, MF ^{[1
]}

HUTTON, M ^{[1
]}

WILLIAMS, NS ^{[1
]}

机构：

[1] UNIV NOTTINGHAM HOSP,QUEENS MED CTR,DEPT SURG,NOTTINGHAM NG7 2UH,ENGLAND

来源：

BRITISH JOURNAL OF SURGERY | 1995年 / 82卷 / 01期

关键词：

D O I：

10.1002/bjs.1800820115

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The rate of oxidation of butyrate, glutamine and glucose was investigated in terminal ileal mucosal biopsy samples from nine patients with ulcerative colitis undergoing restorative proctocolectomy and from 12 patients undergoing laparotomy for reasons other than ulcerative colitis. Substrate oxidation was assayed using a radiolabelled isotope technique. Butyrate was the preferred fuel substrate, followed by glutamine and then glucose (median (95 per cent confidence interval) 567 (262-894), 63 (35-123) and 8.1 (5.1-18) pmol mu g(-1) h(-1) respectively; P<0.01, Mann-Whitney U test) in normal terminal ileal mucosa. The patients with ulcerative colitis had a significantly reduced rate of butyrate oxidation compared with the control group (194 (81-321) versus 567 (262-894) pmol mu g(-1) h(-1), P<0.05). Normal terminal ileal mucosa oxidized butyrate in greater quantities than glucose and glutamine. Ulcerative colitic terminal ileal mucosa exhibited an impaired rate of butyrate oxidation.

引用

页码：36 / 38

页数：3

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