VINYL SULFONES AS MECHANISM-BASED CYSTEINE PROTEASE INHIBITORS

被引:486
|
作者
PALMER, JT
RASNICK, D
KLAUS, JL
BROMME, D
机构
[1] Khepri Pharmaceuticals, Inc., South San Francisco, California 94080
关键词
D O I
10.1021/jm00017a002
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:3193 / 3196
页数:4
相关论文
共 50 条
  • [31] Characterization of the human cytomegalovirus protease as an induced-fit serine protease and the implications to the design of mechanism-based inhibitors
    LaPlante, SR
    Bonneau, PR
    Aubry, N
    Cameron, DR
    Déziel, R
    Grand-Maître, E
    Plouffe, C
    Tong, L
    Kawai, SH
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (13) : 2974 - 2986
  • [32] Involvement of cysteine protease inhibitors in the defense mechanism against parasites
    Izuhara, Kenji
    Kanaji, Sachiko
    Arima, Kazuhiko
    Ohta, Shoichiro
    Shiraishi, Hiroshi
    MEDICINAL CHEMISTRY, 2008, 4 (04) : 322 - 327
  • [33] Solid-phase synthesis of peptide vinyl sulfones as potential inhibitors and activity-based probes of cysteine proteases
    Wang, G
    Mahesh, U
    Chen, GYJ
    Yao, SQ
    ORGANIC LETTERS, 2003, 5 (05) : 737 - 740
  • [34] Higher α-(1-fluoro)vinyl amino acids as mechanism-based enzyme inhibitors.
    Berkowitz, DB
    de la Salud-Bea, R
    Jahng, WJ
    McFadden, JM
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 220 : U65 - U65
  • [35] Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain
    Roush, WR
    Cheng, JM
    Knapp-Reed, B
    Alvarez-Hernandez, A
    McKerrow, JH
    Hansell, E
    Engel, JC
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (20) : 2759 - 2762
  • [36] DESIGN OF AN EFFECTIVE MECHANISM-BASED INACTIVATOR FOR A ZINC PROTEASE
    MOBASHERY, S
    GHOSH, SS
    TAMURA, SY
    KAISER, ET
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (02) : 578 - 582
  • [37] ENZYME-ACTIVATED MECHANISM-BASED INHIBITORS
    PALFREYMAN, MG
    BEY, P
    SJOERDSMA, A
    ESSAYS IN BIOCHEMISTRY, 1987, 23 : 28 - 81
  • [38] Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones
    Shenai, BR
    Lee, BJ
    Alvarez-Hernandez, A
    Chong, PY
    Emal, CD
    Neitz, RJ
    Roush, WR
    Rosenthal, PJ
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (01) : 154 - 160
  • [39] Mechanism-based inhibitors for the inactivation of the bacterial phosphotriesterase
    Hong, SB
    Mullins, LS
    Shim, HB
    Raushel, FM
    BIOCHEMISTRY, 1997, 36 (29) : 9022 - 9028
  • [40] Mechanism-Based Macrocyclic Inhibitors of Serine Proteases
    Damalanka, Vishnu C.
    Banas, Victoria
    De Bona, Paolo
    Kashipathy, Maithri M.
    Battaile, Kevin
    Lovell, Scott
    Janetka, James W.
    JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (06) : 4833 - 4854