PHARMACOLOGICAL DIFFERENTIATION OF THE EFFECTS OF COACTIVATION OF BETA-ADRENERGIC AND METABOTROPIC GLUTAMATE RECEPTORS IN RAT HIPPOCAMPUS

被引：17
|
作者：
GEREAU, RW
WINDER, DG
CONN, PJ
机构：
[1] EMORY UNIV,SCH MED,DEPT PHARMACOL,ATLANTA,GA 30332
[2] EMORY UNIV,SCH MED,PROGRAM NEUROSCI,ATLANTA,GA 30332
来源：
NEUROSCIENCE LETTERS | 1995年 / 186卷 / 2-3期
关键词：
METABOTROPIC GLUTAMATE RECEPTOR; ADENYLYL CYCLASE; (2(S),1(R),2(R),3(R))-2-(2,3-DICARBOXYCYCLPROPYL)GLYCINE (DCG-IV) 3,5-DIHYDROXYPHENYLGLYCINE; BETA-ADRENERGIC RECEPTOR; PHOSPHOINOSITIDE HYDROLYSIS;
D O I：
10.1016/0304-3940(95)11300-L
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Activation of metabotropic glutamate receptors (mGluRs) can potentiate the cAMP response elicited by activation of B-adrenergic receptors (beta ARs) in the hippocampus. We have shown that co-activation of mGluRs and beta ARs induces both an acute depression of excitatory synaptic transmission and a long-lasting excitation of CA1 pyramidal cells. However, these studies were performed using a non-selective mGluR agonist. We have now used subtype selective mGluR agonists, and report that while the acute depression of transmission exhibits a pharmacology consistent with mediation by this mGluR subtype, the lasting excitation of CA1 pyramidal cells may be mediated by an interaction between beta ARs and mGluRs that are coupled to phosphoinositide hydrolysis.
引用
收藏
页码：119 / 122
页数：4
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