PROTEIN-KINASE-C DIRECTLY PHOSPHORYLATES THE INSULIN-RECEPTOR INVITRO AND REDUCES ITS PROTEIN-TYROSINE KINASE-ACTIVITY

被引:271
作者
BOLLAG, GE [1 ]
ROTH, RA [1 ]
BEAUDOIN, J [1 ]
MOCHLYROSEN, D [1 ]
KOSHLAND, DE [1 ]
机构
[1] STANFORD UNIV,MED CTR,SCH MED,DEPT PHARMACOL,STANFORD,CA 94305
关键词
D O I
10.1073/pnas.83.16.5822
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:5822 / 5824
页数:3
相关论文
共 24 条
[1]   THE MOLECULAR-BASIS OF COMMUNICATION WITHIN THE CELL [J].
BERRIDGE, MJ .
SCIENTIFIC AMERICAN, 1985, 253 (04) :142-&
[2]  
COCHET C, 1984, J BIOL CHEM, V259, P2553
[3]  
COOPER JA, 1983, METHOD ENZYMOL, V99, P387
[4]  
DOWNWARD J, 1985, J BIOL CHEM, V260, P4538
[5]   PROTEIN KINASE-C PHOSPHORYLATES PP60SRC AT A NOVEL SITE [J].
GOULD, KL ;
WOODGETT, JR ;
COOPER, JA ;
BUSS, JE ;
SHALLOWAY, D ;
HUNTER, T .
CELL, 1985, 42 (03) :849-857
[6]   AFFINITY ALTERATION OF INSULIN-RECEPTOR INDUCED BY A PHORBOL ESTER [J].
GRUNBERGER, G ;
GORDEN, P .
AMERICAN JOURNAL OF PHYSIOLOGY, 1982, 243 (04) :E319-E324
[7]   AT LAST THE INSULIN-RECEPTOR [J].
HUNTER, T .
NATURE, 1985, 313 (6005) :740-741
[8]   PHORBOL ESTERS STIMULATE THE PHOSPHORYLATION OF RECEPTORS FOR INSULIN AND SOMATOMEDIN-C [J].
JACOBS, S ;
SAHYOUN, NE ;
SALTIEL, AR ;
CUATRECASAS, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (20) :6211-6213
[9]  
JACOBS S, 1985, CANCER CELLS, V3, P139
[10]  
KADOWAKI T, 1984, J BIOL CHEM, V259, P4208