RAPID ENZYMATIC DEGRADATION OF GROWTH-HORMONE RELEASING HORMONE BY PLASMA INVITRO AND INVIVO TO A BIOLOGICALLY INACTIVE PRODUCT CLEAVED AT THE NH2 TERMINUS

被引：146
作者：
FROHMAN, LA
DOWNS, TR
WILLIAMS, TC
HEIMER, EP
PAN, YCE
FELIX, AM
机构：
[1] ROCHE INST MOLEC BIOL,RES CTR,DEPT PEPTIDE RES,NUTLEY,NJ 07110
[2] ROCHE INST MOLEC BIOL,RES CTR,DEPT PROT BIOCHEM,NUTLEY,NJ 07110
来源：
JOURNAL OF CLINICAL INVESTIGATION | 1986年 / 78卷 / 04期
关键词：
D O I：
10.1172/JCI112679
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
引用
收藏
页码：906 / 913
页数：8
相关论文
共 35 条
[31]   METABOLIC-CLEARANCE AND PLASMA HALF-DISAPPEARANCE TIME OF EXOGENOUS SOMATOSTATIN IN MAN [J].
SHEPPARD, M ;
SHAPIRO, B ;
PIMSTONE, B ;
KRONHEIM, S ;
BERELOWITZ, M ;
GREGORY, M .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1979, 48 (01) :50-53
[32]  
Stein S, 1981, Methods Enzymol, V79, P20
[33]  
THORNER MO, 1986, RECENT PROG HORM RES, V42, P589
[34]   HUMAN PANCREATIC TUMOR-GROWTH HORMONE-RELEASING FACTOR - DOSE-RESPONSE RELATIONSHIPS IN NORMAL MAN [J].
VANCE, ML ;
BORGES, JLC ;
KAISER, DL ;
EVANS, WS ;
FURLANETTO, R ;
THOMINET, JL ;
FROHMAN, LA ;
ROGOL, AD ;
MACLEOD, RM ;
BLOOM, S ;
RIVIER, J ;
VALE, W ;
THORNER, MO .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1984, 58 (05) :838-844
[35]   AN INVITRO MODEL FOR STUDIES OF INTERCELLULAR COMMUNICATION IN CULTURED RAT ANTERIOR-PITUITARY CELLS [J].
WILFINGER, WW ;
LARSEN, WJ ;
DOWNS, TR ;
WILBUR, DL .
TISSUE & CELL, 1984, 16 (04) :483-497
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