RAPID ENZYMATIC DEGRADATION OF GROWTH-HORMONE RELEASING HORMONE BY PLASMA INVITRO AND INVIVO TO A BIOLOGICALLY INACTIVE PRODUCT CLEAVED AT THE NH2 TERMINUS

被引：146
作者：
FROHMAN, LA
DOWNS, TR
WILLIAMS, TC
HEIMER, EP
PAN, YCE
FELIX, AM
机构：
[1] ROCHE INST MOLEC BIOL,RES CTR,DEPT PEPTIDE RES,NUTLEY,NJ 07110
[2] ROCHE INST MOLEC BIOL,RES CTR,DEPT PROT BIOCHEM,NUTLEY,NJ 07110
来源：
JOURNAL OF CLINICAL INVESTIGATION | 1986年 / 78卷 / 04期
关键词：
D O I：
10.1172/JCI112679
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
引用
收藏
页码：906 / 913
页数：8
相关论文
共 35 条
[1]  
BARANY G, 1980, PEPTIDES ANAL SYNTHE, V2, P1
[2]  
CHIHARA K, 1986, J CLIN ENDOCR METAB, V62, P466, DOI 10.1210/jcem-62-3-466
[3]   STRUCTURE ACTIVITY STUDIES ON THE N-TERMINAL REGION OF GROWTH-HORMONE RELEASING-FACTOR [J].
COY, DH ;
MURPHY, WA ;
SUEIRASDIAZ, J ;
COY, EJ ;
LANCE, VA .
JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (02) :181-185
[4]   EFFECTS OF INTRAVENOUS, SUBCUTANEOUS, AND INTRANASAL ADMINISTRATION OF GROWTH-HORMONE (GH)-RELEASING HORMONE-40 ON SERUM GH CONCENTRATIONS IN NORMAL MEN [J].
EVANS, WS ;
VANCE, ML ;
KAISER, DL ;
SELLERS, RP ;
BORGES, JLC ;
DOWNS, TR ;
FROHMAN, LA ;
RIVIER, J ;
VALE, W ;
THORNER, MO .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1985, 61 (05) :846-850
[5]  
Frohman L A, 1986, Methods Enzymol, V124, P371
[6]   GROWTH HORMONE AND INSULIN LEVELS IN WEANLING RATS WITH VENTROMEDIAL HYPOTHALAMIC LESIONS [J].
FROHMAN, LA ;
BERNARDIS, LL .
ENDOCRINOLOGY, 1968, 82 (06) :1125-+
[7]   METABOLIC-CLEARANCE AND PLASMA DISAPPEARANCE RATES OF HUMAN PANCREATIC TUMOR-GROWTH HORMONE-RELEASING FACTOR IN MAN [J].
FROHMAN, LA ;
THOMINET, JL ;
WEBB, CB ;
VANCE, ML ;
UDERMAN, H ;
RIVIER, J ;
VALE, W ;
THORNER, MO .
JOURNAL OF CLINICAL INVESTIGATION, 1984, 73 (05) :1304-1311
[8]   GROWTH HORMONE-RELEASING HORMONE [J].
FROHMAN, LA ;
JANSSON, JO .
ENDOCRINE REVIEWS, 1986, 7 (03) :223-253
[9]   PARTIAL-PURIFICATION AND CHARACTERIZATION OF A PEPTIDE WITH GROWTH HORMONE-RELEASING ACTIVITY FROM EXTRAPITUITARY TUMORS IN PATIENTS WITH ACROMEGALY [J].
FROHMAN, LA ;
SZABO, M ;
BERELOWITZ, M ;
STACHURA, ME .
JOURNAL OF CLINICAL INVESTIGATION, 1980, 65 (01) :43-54
[10]  
GELATO MC, 1984, EXCERPTA MED INT C S, V652, P605
1234