NATURAL-PRODUCTS AS A SOURCE OF POTENTIAL CANCER CHEMOTHERAPEUTIC AND CHEMOPREVENTIVE AGENTS

被引：191
作者：
CASSADY, JM [1 ]
BAIRD, WM [1 ]
CHANG, CJ [1 ]
机构：
[1] PURDUE UNIV, SCH PHARM & PHARMACEUT SCI, W LAFAYETTE, IN 47907 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 1990年 / 53卷 / 01期
关键词：
D O I：
10.1021/np50067a003
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Recent advances in the chemistry of novel bioactive natural products are reported. This research is directed to the exploration of plants with confirmed activity in bioassays designed to detect potential cancer chemotherapeutic and chemopreventive agents. Structural work and chemical studies are reported for several cytotoxic agents from the plants Annona densicoma, Annona reticulata, Claopodium crispifolium, Polytrichum ohioense, and Psorospermum febrifugum. Studies are also reported based on development of a mammalian cell culture benzo[a]pyrene metabolism assay for the detection of potential anticarcinogenic agents from natural products. In this study a number of isoflavonoids and flavonoids with antimutagenic activity have been discovered. © 1990, American Chemical Society. All rights reserved.
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页码：23 / 41
页数：19
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