Costello Syndrome with Severe Nodulocystic Acne: Unexpected Significant Improvement of Acanthosis Nigricans after Oral Isotretinoin Treatment

被引：4

作者：

Sriboonnark, Leelawadee ^{[1
]}

Arora, Harleen ^{[2
]}

Falto-Aizpurua, Leyre ^{[2
]}

Choudhary, Sonal ^{[2
]}

Connelly, Elizabeth Alvarez ^{[2
]}

机构：

[1] Khon Kaen Univ, Fac Med, Dept Pediat, Div Dermatol, Khon Kaen 40002, Thailand

[2] Univ Miami, Dept Pediat Dermatol, Miller Sch Med, Miami, FL 33136 USA

来源：

CASE REPORTS IN PEDIATRICS | 2015年 / 2015卷

关键词：

D O I：

10.1155/2015/934865

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We report the case of 17-year-old female diagnosed with Costello syndrome. Genetic testing provided a proof with G12Smutation in the HRAS gene since 3 years of age with a presentation of severe nodulocystic acne on her face. After 2 months of oral isotretinoin treatment, improvement in her acne was observed. Interestingly, an unexpected significant improvement of acanthosis nigricans on her neck and dorsum of her hands was found as well. We present this case as a successful treatment option by using oral isotretinoin for the treatment of acanthosis nigricans in Costello syndrome patients.

引用

页数：4

共 37 条

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