Description of 3 Cases in Vietnam of Aspirin Desensitization in Patients With Coronary Artery Disease and Coexisting Aspirin Hypersensitivity

被引：6

作者：

Dinh Van Nguyen ^{[1
,2
]}

Chi, Hieu Chu ^{[2
]}

Doan Van Nguyen ^{[1
,2
]}

Craig, Timothy J. ^{[3
]}

van Nunen, Sheryl ^{[4
,5
]}

机构：

[1] Hanoi Med Univ, Allergy Dept, Hanoi, Vietnam

[2] Bach Mai Hosp, Ctr Allergol & Clin Immunol, Hanoi, Vietnam

[3] Penn State Univ, Sect Allergy Asthma & Immunol, Hershey, PA USA

[4] Univ Sydney, Sydney Med Sch Northern, Sydney, NSW, Australia

[5] Royal North Shore Hosp, Dept Clin Immunol & Allergy, Sydney, NSW, Australia

来源：

WORLD ALLERGY ORGANIZATION JOURNAL | 2012年 / 5卷

关键词：

Vietnam; aspirin (ASA) hypersensitivity; ASA desensitization; coronary artery disease;

D O I：

10.1097/WOX.0b013e3182718327

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Aspirin (ASA) hypersensitivity comprises types I to III (Cox-1 mediated) and types IV and V (IgE antibody mediated). Rapid, low-dose (81-325 mg/day) ASA desensitization regimens are known to be useful in establishing ASA tolerance in patients with coronary artery disease and coexisting ASA/nonsteroidal anti-inflammatory drug hypersensitivity. We document 3 cases in Vietnam of desensitization to ASA in patients with coronary artery disease and coexisting ASA hypersensitivity. One of these 3 patients had probable immune-mediated hypersensitivity, whereas the remaining 2 had probable Cox-1-mediated reactions. The regimen of desensitization we employed for each patient was designed to account for the probable mechanism of hypersensitivity in the individual and further modified according to the degree of tolerance observed, with all 3 patients eventually achieving a daily cardioprotective dosage of ASA.

引用

页码：170 / 173

页数：4

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