A NOVEL DODECADEPSIPEPTIDE, CEREULIDE, IS AN EMETIC TOXIN OF BACILLUS-CEREUS

被引：2

作者：

AGATA, N

OHTA, M

MORI, M

ISOBE, M

机构：

[1] NAGOYA UNIV,SCH MED,DEPT BACTERIOL,NAGOYA,AICHI 466,JAPAN

[2] NAGOYA UNIV,SCH AGR SCI,ORGAN CHEM LAB,NAGOYA,AICHI 46401,JAPAN

来源：

FEMS MICROBIOLOGY LETTERS | 1995年 / 129卷 / 01期

关键词：

BACILLUS CEREUS; CEREULIDE; EMESIS; SUNCUS MURINUS; HEP-2; CELL; VALINOMYCIN;

D O I：

暂无

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A vacuole-formation substance, cereulide of Bacillus cereus, is an emetic toxin in animals. Both oral administration and intraperitoneal injection of cereulide caused dose-dependent emesis in Suncus murinus, a new animal model of emesis. Vagotomy or a 5-HT3 receptor antagonist completely abolished this emetic effect. Therefore, cereulide causes emesis through the 5-HT3 receptor and stimulation of the vagus afferent. We also found that our purified cereulide caused swelling of mitochondria of HEp-2 cells.

引用

页码：17 / 19

页数：3