OBSERVATIONS OF PRETREATMENT PROSTATE-SPECIFIC ANTIGEN DOUBLING TIME IN 107 PATIENTS REFERRED FOR DEFINITIVE RADIOTHERAPY

被引:32
作者
LEE, WR
HANKS, GE
CORN, BW
SCHULTHEISS, TE
机构
[1] Fox Chase Cancer Center, Department of Radiation Oncology, Philadelphia, PA 19177
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1995年 / 31卷 / 01期
关键词
PSA; PSA DOUBLING TIME; PROSTATE CANCER; RADIOTHERAPY; NATURAL HISTORY;
D O I
10.1016/0360-3016(94)00339-M
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: To determine pretreatment prostate-specific antigen doubling times (PSADT) in patients referred for definitive radiotherapy. Methods and Materials: One hundred and seven patients with histologically proven nonmetastatic prostate cancer and an elevated prostate-specific antigen (PSA) who were referred for radiation therapy had three serum PSA values obtained prior to the start of definitive therapy. Prostate-specific antigen doubling times were calculated by linear regression. Results: Prostate-specific antigen values increased during the period of observation in 78 patients (73%). Forty-three patients (40%) had calculated PSADT of less than 2 years and of those patients with pretreatment serum PSA values of greater than 10 ng/mL more than 50% has calculated PSADT of less than 2 years. Conclusions: A significant minority of patients referred for radiotherapy have calculated PSADT of less than 2 years. The significance of this relatively fast growth rate is as yet undetermined, but suggests that patients referred for radiotherapy may have aggressive disease prior to treatment.
引用
收藏
页码:21 / 24
页数:4
相关论文
共 19 条
[1]   NATURAL COURSE OF CLINICALLY LOCALIZED PROSTATE ADENOCARCINOMA IN MEN LESS THAN 70-YEARS-OLD [J].
ADOLFSSON, J ;
CARSTENSEN, J .
JOURNAL OF UROLOGY, 1991, 146 (01) :96-98
[2]   PROSTATE-SPECIFIC ANTIGEN KINETICS AFTER EXTERNAL-BEAM IRRADIATION FOR CARCINOMA OF THE PROSTATE [J].
COX, RS ;
KAPLAN, ID ;
BAGSHAW, MA .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1994, 28 (01) :23-31
[3]   TOTAL PROSTATECTOMY FOR LOCALIZED PROSTATIC-CANCER [J].
GIBBONS, RP ;
CORREA, RJ ;
BRANNEN, GE ;
MASON, JT .
JOURNAL OF UROLOGY, 1984, 131 (01) :73-76
[4]   HISTOLOGIC GRADING OF PROSTATE-CANCER - A PERSPECTIVE [J].
GLEASON, DF .
HUMAN PATHOLOGY, 1992, 23 (03) :273-279
[5]   PROSTATIC-SPECIFIC ANTIGEN DOUBLING TIMES IN PATIENTS WITH PROSTATE-CANCER - A POTENTIALLY USEFUL REFLECTION OF TUMOR DOUBLING TIME [J].
HANKS, GE ;
DAMICO, A ;
EPSTEIN, BE ;
SCHULTHEISS, TE .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1993, 27 (01) :125-127
[6]  
HANKS GE, 1993, CANCER PRINCIPLES PR, P1073
[7]   HIGH 10-YEAR SURVIVAL RATE IN PATIENTS WITH EARLY, UNTREATED PROSTATIC-CANCER [J].
JOHANSSON, JE ;
ADAMI, HO ;
ANDERSSON, SO ;
BERGSTROM, R ;
HOLMBERG, L ;
KRUSEMO, UB .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1992, 267 (16) :2191-2196
[8]  
MCNEAL JE, 1986, LANCET, V1, P60
[9]  
MCNEAL JE, 1969, CANCER, V23, P24, DOI 10.1002/1097-0142(196901)23:1<24::AID-CNCR2820230103>3.0.CO
[10]  
2-1