ELECTROLYTE-INDUCED DEMYELINATION IN RATS .1. ROLE OF THE BLOOD-BRAIN-BARRIER AND EDEMA

被引:0
作者
ROJIANI, AM
PRINEAS, JW
CHO, ES
机构
[1] UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,DEPT PATHOL,NEWARK,NJ 07103
[2] UNIV FLORIDA,COLL MED,DEPT PATHOL,GAINESVILLE,FL
[3] UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,DEPT NEUROSCI,NEWARK,NJ 07103
关键词
BLOOD-BRAIN-BARRIER; CENTRAL PONTINE MYELINOLYSIS; ELECTROLYTE-INDUCED DEMYELINATION; OLIGODENDROCYTE; PATHOGENESIS;
D O I
暂无
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The blood-brain barrier (BBB) was studied in rats with electrolyte-induced demyelnation (EID), an experimental model for central pontine myelinolysis. Intravenously injected peroxidase was extravasated at 3 h post hypertonic saline injection (PI-IS) into regions frequently involved in EID. Increased pinocytotic activity and focal interendothelial gaps were seen at 3 h PHS and less frequently at 48 h PHS. Measurement of total cerebral water content revealed an increase during the hyponatremic phase. This was followed by a marked increase at 3 h PHS with continued increment at 48 h PHS. Intracellular edema with accumulation of fluid within neurites and astrocytic processes was noted during the hyponatremic phase, whereas extracellular edema developed after hypertonic saline injection. The implications of disrupted BBB and its role in the pathogenesis of EID are discussed.
引用
收藏
页码:287 / 292
页数:6
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