MORPHOLOGICAL-CHANGES OF CULTURED ENDOTHELIAL-CELLS AFTER MICROINJECTION OF TOXINS THAT ACT ON THE CYTOSKELETON

被引：0
|
作者：
MULLER, H
VONEICHELSTREIBER, C
HABERMANN, E
机构：
[1] UNIV GIESSEN,RUDOLF BUCHHEIM INST PHARMACOL,FRANKFURTER STR 107,W-6300 GIESSEN,GERMANY
[2] INST MED MICROBIOL,W-6500 MAINZ,GERMANY
来源：
INFECTION AND IMMUNITY | 1992年 / 60卷 / 07期
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Clostridium novyi alpha-toxin and C. difficile toxins A and B (all 200 to 300 kDa) and C. botulinum C2-I toxin (50 kDa) caused a delayed and persistent retraction and rounding of microinjected cells. Microinjected phalloidin acted fast and reversibly. Unlike C2-I toxin, phalloidin passed through the intercellular junctions. Specific antitoxin applied to the medium did not prevent the action of microinjected C. novyi or C. difficile toxin B. Microinjected antitoxin protected against the toxins applied with the medium or injected into the same cells.
引用
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页码：3007 / 3010
页数：4
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