THE INFLUENCE OF TUMOR-CELL DNA CONTENT ON SURVIVAL IN COLORECTAL-CANCER - A DETAILED ANALYSIS

被引：45

作者：

ARMITAGE, NC ^{[1
]}

BALLANTYNE, KC ^{[1
]}

EVANS, DF ^{[1
]}

CLARKE, P ^{[1
]}

SHEFFIELD, J ^{[1
]}

HARDCASTLE, JD ^{[1
]}

机构：

[1] ST MARKS HOSP,DEPT HISTOPATHOL,LONDON EC1,ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1990年 / 62卷 / 05期

关键词：

D O I：

10.1038/bjc.1990.393

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have investigated the influence of tumour cell DNA content (ploidy) on survival of 416 patients undergoing excisional surgery for colorectal cancer. Two hundred and eleven (51%) tumours had an abnormal DNA content (aneuploid or tetraploid). There was no correlation between ploidy status, sex, age and pathological stage, histological grade, tumour site, local tumour extension or assessment of curability. Patients with tumours with an abnormal DNA content had a poorer survival 68/211 (32%) than patients with near normal (diploid) DNA content 88/205 (43%) (test statistic 5.0, P = 0.02). The patient subgroups in which DNA content exerted an influence on survival were: stage B tumours (P = 0.058), moderately differentiated tumours (P = 0.004), rectal tumours (P = 0.02), and mobile tumours (P = 0.02). Multivariant analysis showed that pathological stage, local tumour extension and DNA ploidy were all independent prognostic indicators whereas histological grade, tumour site and assessment of ‘curability’ were not. The influence of pathological stage, however, was much greater than that of local tumour extension or DNA ploidy. Tumour cell DNA content together with pathological stage and local tumour extension may be used in a prognostic index and may be important in planning adjuvant therapy. © Macmillan Press Ltd., 1990.

引用

页码：852 / 856

页数：5

共 23 条

[1] THE INFLUENCE OF TUMOR-CELL DNA ABNORMALITIES ON SURVIVAL IN COLORECTAL-CANCER [J].