ENHANCED SENSITIVITY TO CHOLECYSTOKININ TETRAPEPTIDE IN PANIC DISORDER - CLINICAL AND BEHAVIORAL FINDINGS

被引：0

作者：

BRADWEJN, J ^{[1
]}

KOSZYCKI, D ^{[1
]}

SHRIQUI, C ^{[1
]}

机构：

[1] MCGILL UNIV,DEPT PSYCHIAT,MONTREAL H3A 2T5,QUEBEC,CANADA

来源：

ARCHIVES OF GENERAL PSYCHIATRY | 1991年 / 48卷 / 07期

关键词：

D O I：

暂无

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

We studied the action of cholecystokinin tetrapeptide (CCK-4) in patients with panic disorder and normal controls. Subjects received, in random order, one injection of CCK-4 and one injection of placebo (saline) on two separate days in a double-blind crossover design. Two doses of CCK-4, 50 and 25-mu-g, were administered to two different samples of subjects. The panic rate with 50-mu-g of CCK-4 was 100% (12/12) for patients and 47% (7/15) for controls. The panic rate with 25-mu-g of CCK-4 was 91% (10/11) for patients and 17% (2/12) for controls. Nine percent of patients compared with 0% of controls panicked with placebo. These findings concur with previous reports of a panicogenic effect of CCK-4 and suggest that patients with panic disorder are more sensitive to the panicogenic effect of the peptide than are normal controls.

引用

页码：603 / 610

页数：8