ENHANCED SENSITIVITY TO CHOLECYSTOKININ TETRAPEPTIDE IN PANIC DISORDER - CLINICAL AND BEHAVIORAL FINDINGS

被引:0
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作者
BRADWEJN, J [1 ]
KOSZYCKI, D [1 ]
SHRIQUI, C [1 ]
机构
[1] MCGILL UNIV,DEPT PSYCHIAT,MONTREAL H3A 2T5,QUEBEC,CANADA
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中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
We studied the action of cholecystokinin tetrapeptide (CCK-4) in patients with panic disorder and normal controls. Subjects received, in random order, one injection of CCK-4 and one injection of placebo (saline) on two separate days in a double-blind crossover design. Two doses of CCK-4, 50 and 25-mu-g, were administered to two different samples of subjects. The panic rate with 50-mu-g of CCK-4 was 100% (12/12) for patients and 47% (7/15) for controls. The panic rate with 25-mu-g of CCK-4 was 91% (10/11) for patients and 17% (2/12) for controls. Nine percent of patients compared with 0% of controls panicked with placebo. These findings concur with previous reports of a panicogenic effect of CCK-4 and suggest that patients with panic disorder are more sensitive to the panicogenic effect of the peptide than are normal controls.
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页码:603 / 610
页数:8
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