STUDIES ON THE INVOLVEMENT OF OPIOID MECHANISM IN THE LOCOMOTOR EFFECTS OF BENZODIAZEPINES IN RATS

被引：8
作者：
NOWAKOWSKA, E [1 ]
CHODERA, A [1 ]
机构：
[1] MED ACAD POZNAN,DEPT PHARMACOL,FREDRY 10S,PL-61701 POZNAN,POLAND
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1991年 / 38卷 / 02期
关键词：
NALOXONE; NITRAZEPAM; TOLERANCE; LOCOMOTOR ACTIVITY;
D O I：
10.1016/0091-3057(91)90276-8
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The influence of the opioid receptor antagonist naloxone upon the reduced locomotor activity after administration of nitrazepam (NTZ) and upon the increased locomotion after chronic nitrazepam administration was tested. It was found that a single dose of naloxone counteracted both the reduced locomotion after acute administration of nitrazepam as well as the augmented locomotor activity after chronic application of nitrazepam. It is assumed that opioid mechanisms are involved in the locomotor effects of benzodiazepines.
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页码：265 / 266
页数：2
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