DNA METHYLATION AND CHROMATIN STRUCTURE

被引：172
|
作者：
LEWIS, J
BIRD, A
机构：
来源：
FEBS LETTERS | 1991年 / 285卷 / 02期
基金：
英国惠康基金;
关键词：
DNA METHYLATION; 5-METHYL CYTOSINE; CHROMATIN; HETEROCHROMATIN; METHYL-CPG BINDING PROTEIN; CPG ISLANDS; X-CHROMOSOME; ACTIVE CHROMATIN; CPG ISLANDS; GLOBIN GENE; 5-METHYLCYTOSINE; REPLICATION; PROTEIN; TIME; SITE;
D O I：
10.1016/0014-5793(91)80795-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Studies of the whole genome by molecular and cytogenetic methods have implicated DNA methylation in the formation of 'inactive chromatin'. This has been confirmed by analysis of specific endogenous sequences, and has been mimicked by introducing methylated and non-methylated sequences into cells. As well as affecting chromatin structure, DNA methylation also represses transcription. A protein (MeCP) which binds specifically to methylated DNA has been identified. The properties of MeCP could account for the effects of DNA methylation on both chromatin and transcription.
引用
收藏
页码：155 / 159
页数：5
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