DETOXIFICATION FROM BENZODIAZEPINES - SCHEDULES AND STRATEGIES

被引:19
作者
ALEXANDER, B
PERRY, PJ
机构
[1] UNIV IOWA,COLL PHARM,DIV CLIN PHARM,QUADRANGLE,IOWA CITY,IA 52242
[2] UNIV IOWA,COLL MED,DEPT PSYCHIAT,IOWA CITY,IA 52242
[3] IOWA CITY VET AFFAIRS MED CTR,DEPT PHARM & PSYCHIAT,IOWA CITY,IA
关键词
BENZODIAZEPINES; TOLERANCE; WITHDRAWAL; TREATMENT; ABUSE;
D O I
10.1016/0740-5472(91)90022-3
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Management of benzodiazepine (BZD) tolerance is divided into low-and high-dose withdrawal. Low-dose withdrawal includes patients who have recieved manufacturer-recommended doses of BZD on a daily basis for longer than 1 month. Gradual tapering of the BZD over 4 weeks on an outpatient basis is suggested. High-dose withdrawal includes patients who have been ingesting doses of BZD greater than the equivalent of diazepam 40 mg/d for longer than 8 months. It is recommended that the patients be tolerance tested with diazepam and, if tolerant, tapered off medication as inpatients at a rate of 10% per day. Triazolobenzodiazepines may be exceptions to these recommendations. Alprazolam should be titrated at a rate of 0.5 mg three times a day regardless of whether the patient is being tapered for low- or high-dose withdrawal. © 1991.
引用
收藏
页码:9 / 17
页数:9
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